Monday, February 16, 2026 2/16/2026

DNA REPAIR BIOMARKERS FOR CANCER RISK ASSESSMENT AND EA*

Award Number: U01CA111219
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2005
PERIOD OF PERFORMANCE END DATE: 07/31/2011

Group Awards By:

View Award Description

DNA REPAIR BIOMARKERS FOR CANCER RISK ASSESSMENT AND EA* - DESCRIPTION (provided by applicant): DNA repair emerged as an important factor in cancer pathogenesis, with the discovery that in several hereditary cancer-prone diseases, the predisposing mutations are in genes encoding DNA repair proteins. The long-term goal of the proposed research is to harness the molecular understanding of DNA repair mechanisms to cancer prevention, by developing a battery DNA repair biomarkers for cancer risk assessment, and apply them to large-scale screening. A first step in this direction was done by the PI in a recent study, in which a functional enzymatic activity assay was developed for the repair of the oxidative DNA lesion 8-oxoguanine in extracts from human peripheral blood mononuclear cells. Using that assay evidence was obtained to indicate that reduced OGG1 DNA repair activity is a risk factor in lung cancer. The proposed studies are aimed to extend and broaden that initial study. Specifically it is proposes: (1) To develop three blood tests for the repair of DNA lesions formed by oxidative stress, and for the elimination of oxidation-damaged nucleotides from the DNA precursor pool. (2) To perform within-laboratory reproducibility studies with these tests. (3) To perform proof-of-principle small-scale case-control studies in order to examine whether reduced levels of the DNA repair and damage prevention activities under investigation are associated with the risk of lung cancer. (4) To examine the correlation between the DNA repair activities in peripheral blood mononuclear cells and lung tissue from lung cancer patients. A between-laboratory reproducibility study will then be initiated with the tests within the Early Detection Research Network. Future successful validation will enable to take the further necessary steps, before application to public health can be made in large-scale population screening for purposes of cancer prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	WEIZMANN INSTITUTE OF SCIENCE	POST OFFICE BOX 26	REHOVOTH		00000		ISR	Cancer Control	000	5	11/4/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $149,921 )
2009	2009	WEIZMANN INSTITUTE OF SCIENCE	POST OFFICE BOX 26	REHOVOTH				ISL	Cancer Control	000	5	7/14/2009	NON-COMPETING CONTINUATION	$149,921
														Subtotal = $149,921

Issue Date FY: 2008 ( Subtotal = $246,995 )
2008	2008	WEIZMANN INSTITUTE OF SCIENCE	POST OFFICE BOX 26	REHOVOTH		00000		ISR	Cancer Control	000	4	8/28/2008	NON-COMPETING CONTINUATION	$246,995
														Subtotal = $246,995

Issue Date FY: 2007 ( Subtotal = $239,509 )
2007	2007	WEIZMANN INSTITUTE OF SCIENCE	POST OFFICE BOX 26	REHOVOTH		00000		ISR	Cancer Control	000	3	9/5/2007	NON-COMPETING CONTINUATION	$239,509
														Subtotal = $239,509

Issue Date FY: 2006 ( Subtotal = $274,232 )
2006	2006	WEIZMANN INSTITUTE OF SCIENCE	POST OFFICE BOX 26	REHOVOTH		00000		ISR	Cancer Control	000	2	8/17/2006	NON-COMPETING CONTINUATION	$274,232
														Subtotal = $274,232

Grand Total All Awards = $910,657

Top

All Categories

About

Search

Reports

Data Submission

Award Information

DNA REPAIR BIOMARKERS FOR CANCER RISK ASSESSMENT AND EA*

Award Number: U01CA111219

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2005

PERIOD OF PERFORMANCE END DATE: 07/31/2011

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer