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HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial

Award Number: U01AR080377
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT The proposed trial, HIP ATTACK-2, seeks to improve the outcomes of thousands of patients who present to the hospital with a hip fracture and concomitant acute heart injury. Acute heart injury is characterized by an elevated serum troponin; this heart injury is often asymptomatic but can be identified in up to 20% of hip fracture patients prior to surgery. These patients have a much worse prognosis than patients with no heart injury (i.e., 24% versus 8% 90-day mortality, respectively). Despite the magnitude of this problem, standard medical management has made little progress in improving the outcomes of these patients. The objective of the HIP ATTACK-2 trial is to confirm the previous post-hoc subgroup findings by comparing accelerated surgery (<6 hours) to standard care in hip fracture patients presenting with elevated serum troponin. This multicenter, parallel group randomized controlled trial will address three specific aims: 1) to determine if accelerated surgery reduces the risk of 90-day mortality in hip fracture patients who also have an acute heart injury, 2) to determine if accelerated surgery increases the proportion of patients able to independently ambulate 10 feet at 90-days, 3) to determine if accelerated surgery improves patient-reported quality of life and decreases medical and surgical complications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $982,071 )
2023	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/31/2023	NON-COMPETING CONTINUATION	$982,071
														Subtotal = $982,071

Issue Date FY: 2022 ( Subtotal = $1,004,029 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/29/2022	NEW	$1,004,029
														Subtotal = $1,004,029

Grand Total All Awards = $1,986,100

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HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial

Award Number: U01AR080377

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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