Wednesday, January 15, 2025 1/15/2025

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center

Award Number: U01AR071158
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM- 23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $747,994 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	8	8/13/2024	NON-COMPETING CONTINUATION	$747,994
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	006	8	9/4/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	000	6	11/17/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	7	11/28/2023	COMPETING CONTINUATION	$952,499
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	7	3/11/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	003	6	11/28/2023	SUPPLEMENT FOR EXPANSION	-$46,497
2024	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	001	6	11/28/2023	NON-COMPETING CONTINUATION	-$906,002
														Subtotal = $747,994

Issue Date FY: 2023 ( Subtotal = $1,456,514 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	001	6	8/17/2023	SUPPLEMENT FOR EXPANSION	$46,497
2023	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	7	9/21/2023	COMPETING CONTINUATION	$1,410,017
2023	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	002	6	9/20/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Trans-NIH Research Support	000	6	12/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,456,514

Issue Date FY: 2022 ( Subtotal = $1,309,171 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	6	12/3/2021	NON-COMPETING CONTINUATION	$1,309,171
														Subtotal = $1,309,171

Issue Date FY: 2021 ( Subtotal = $1,331,523 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	001	5	12/20/2020	NON-COMPETING CONTINUATION	$1,309,171
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	002	5	7/11/2021	SUPPLEMENT FOR EXPANSION	$22,352
2021	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	4	12/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,331,523

Issue Date FY: 2020 ( Subtotal = $1,050,378 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	001	4	9/17/2020	SUPPLEMENT FOR EXPANSION	$35,941
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	4	2/13/2020	NON-COMPETING CONTINUATION	$1,014,437
														Subtotal = $1,050,378

Issue Date FY: 2019 ( Subtotal = $1,017,787 )
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	3	1/8/2019	NON-COMPETING CONTINUATION	$1,017,787
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	001	3	3/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,017,787

Issue Date FY: 2018 ( Subtotal = $783,535 )
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	2	2/21/2018	NON-COMPETING CONTINUATION	$783,535
														Subtotal = $783,535

Issue Date FY: 2017 ( Subtotal = $254,500 )
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	001	1	9/20/2017	NEW	$100,000
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$154,500
														Subtotal = $254,500

Grand Total All Awards = $7,951,402

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Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center

Award Number: U01AR071158

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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