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The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical Center

Award Number: U01AR071133
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers (the `molecular map') that underlie the effects of physical activity (PA) in humans. We formed an interdisciplinary team with the requisite experiences to contribute significantly to the overall success of MoTrPAC. Our Exercise and Physical Activity Collaborative Team (ExPACT) – an alliance of the University of Alabama at Birmingham Center for Exercise Medicine (UAB), Translational Research Institute for Metabolism and Diabetes in Orlando, Florida (TRI-MD), and Ball State University Human Performance Laboratory (BSU) – has extensive experience performing highly-controlled aerobic (AT) and resistance (RT) exercise training clinical trials in healthy and diseased populations. We have a lengthy history of maximizing human biospecimens (muscle, adipose, blood) to reveal molecular underpinnings linked to physiological and clinical outcomes of acute and chronic exercise stimuli. Moreover, the overarching goal of ExPACT is to contribute substantively to successful MoTrPAC planning, execution, and innovation. Phase I (Planning Year) Aim 1. We will effectively collaborate with MoTrPAC leaders and NIH leadership to help guide and finalize the structure and standard operating procedures (SOPs). Aim 2. Leveraging institutional resources committed to ExPACT and our previous experience, we propose to collect pilot biospecimens to facilitate the MoTrPAC Chemical Analysis Sites' ability to optimize analyses. Phase II (Recruitment and Testing Years 2-5) Aim 1. We will enroll 420 sedentary but healthy men and women 18+ y into a rigorously controlled, 12-wk, randomized trial of AT (n=185), RT (n=185), or no-exercise control (CON, n=50). ExPACT geography will enrich MoTrPAC racial, ethnic, urban, suburban, and rural diversity. The design incorporates comprehensive phenotyping to assess fitness and clinical outcomes, and human tissue phenotyping to link the molecular transducers with key biological responses to exercise. Aim 2. Pre- and post- training, we will obtain strategically timed biospecimens before and after acute exercise. To better understand the biological extremes, we will conduct the same acute response studies in highly-trained athletes (AT (n=20) or RT (n=20)). Serial biospecimen collection in CON will allow estimation of biological, seasonal, circadian and methodological variability. Aim 3. To enhance the overall scientific impact of MoTrPAC, we will seek additional funding to conduct innovative ancillary studies, which will markedly augment subject and tissue phenotyping and interpretation of the molecular maps. Phase III (Close-out Year 6) Aim 1. We will complete all ExPACT data entry, quality control, and central deposit procedures in collaboration with the MoTrPAC Coordinating Center, and we will actively contribute to the completion of biospecimen analyses, manuscript writing, and dissemination of results. We would be honored to collaborate with MoTrPAC to contribute future knowledge on the molecular mechanisms through which physical activity can improve or preserve health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,152,457 )
2023	2023	BALL STATE UNIVERSITY	2000 W. UNIVERSITY AVENUE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	001	6	8/17/2023	SUPPLEMENT FOR EXPANSION	$97,842
2023	2023	BALL STATE UNIVERSITY	2000 W. UNIVERSITY AVENUE	MUNCIE	IN	47306	DELAWARE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	7	9/19/2023	COMPETING CONTINUATION	$2,054,615
2023	2022	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	000	6	10/26/2022	NON-COMPETING CONTINUATION	$0
2023	2022	BALL STATE UNIVERSITY	2000 W. UNIVERSITY AVENUE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	002	6	9/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,152,457

Issue Date FY: 2022 ( Subtotal = $2,375,000 )
2022	2022	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	005	6	12/6/2021	NON-COMPETING CONTINUATION	$2,375,000
2022	2022	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	006	6	12/18/2021	NON-COMPETING CONTINUATION	$0
2022	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	004	5	11/4/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2022	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	002	5	10/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,945,930
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	003	4	10/27/2021	SUPPLEMENT FOR EXPANSION	-$35,942
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	001	4	10/27/2021	NON-COMPETING CONTINUATION	-$2,500,000
2022	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	3	10/27/2021	NON-COMPETING CONTINUATION	-$1,409,988
														Subtotal = $2,375,000

Issue Date FY: 2021 ( Subtotal = $2,468,513 )
2021	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	001	5	1/6/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,375,000
2021	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	007	5	6/10/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,445,930
2021	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	003	5	3/11/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,445,930
2021	2021	BALL STATE UNIVERSITY	2000 UNIVERSITY AVE	MUNCIE	IN	47306	DELAWARE	USA	Trans-NIH Research Support	009	5	7/12/2021	SUPPLEMENT FOR EXPANSION	$93,513
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	008	4	6/10/2021	SUPPLEMENT FOR EXPANSION	$35,942
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	004	4	3/11/2021	SUPPLEMENT FOR EXPANSION	-$35,942
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	005	4	5/4/2021	NON-COMPETING CONTINUATION	$2,500,000
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	4	1/6/2021	NON-COMPETING CONTINUATION	-$2,500,000
2021	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	006	3	6/10/2021	NON-COMPETING CONTINUATION	$1,409,988
2021	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	002	3	3/11/2021	NON-COMPETING CONTINUATION	-$1,409,988
														Subtotal = $2,468,513

Issue Date FY: 2020 ( Subtotal = $2,535,942 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	4	2/13/2020	NON-COMPETING CONTINUATION	$2,500,000
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	002	4	6/2/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	003	4	9/21/2020	SUPPLEMENT FOR EXPANSION	$35,942
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	001	4	4/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,535,942

Issue Date FY: 2019 ( Subtotal = $4,301,428 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	001	3	3/21/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	3	12/26/2018	NON-COMPETING CONTINUATION	$1,780,093
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	003	3	9/11/2019	NON-COMPETING CONTINUATION	$2,499,799
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	002	3	4/3/2019	NON-COMPETING CONTINUATION	$21,536
														Subtotal = $4,301,428

Issue Date FY: 2018 ( Subtotal = $1,497,096 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	2	2/21/2018	NON-COMPETING CONTINUATION	$1,497,096
														Subtotal = $1,497,096

Issue Date FY: 2017 ( Subtotal = $272,527 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	001	1	9/20/2017	NEW	$100,000
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$172,527
														Subtotal = $272,527

Grand Total All Awards = $15,602,963

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The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical Center

Award Number: U01AR071133

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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