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Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

Award Number: U01AR071128
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site - MoTrPAC Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers underlying the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators, not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex-balanced, with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, beginning in March 2020, MoTrPAC activities were suspended for over a year with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, the human clinical centers have successfully enrolled ~80% (adult) and 95% (pediatric) of the highly active cohort, ~93% of cross-sectional (pediatric), and ~60% (adult) and ~50% (pediatric) of the current target enrollment numbers in the randomized control trial portion of the study. This led to the NIH Common Fund to release the current NOFO (RFA-RM-23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children, and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to the understanding of exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned, will provide a more complete public database of the health benefits of exercise, and will provide insight into how physical activity mitigates disease risk.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	8	4/25/2025	NON-COMPETING CONTINUATION	$0
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	1/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,199,897 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	8	9/4/2024	SUPPLEMENT FOR EXPANSION	$99,897
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	8/13/2024	NON-COMPETING CONTINUATION	$1,100,000
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	7	8/16/2024	COMPETING CONTINUATION	$1,157,749
2024	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	001	6	8/16/2024	NON-COMPETING CONTINUATION	-$1,157,749
														Subtotal = $1,199,897

Issue Date FY: 2023 ( Subtotal = $2,535,367 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	7	9/20/2023	COMPETING CONTINUATION	$2,535,367
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Trans-NIH Research Support	000	6	9/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,535,367

Issue Date FY: 2022 ( Subtotal = $2,375,000 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	6	9/1/2022	NON-COMPETING CONTINUATION	$0
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	6	12/6/2021	NON-COMPETING CONTINUATION	$2,375,000
														Subtotal = $2,375,000

Issue Date FY: 2021 ( Subtotal = $2,503,314 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	002	5	9/6/2021	SUPPLEMENT FOR EXPANSION	$128,314
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	5	12/28/2020	NON-COMPETING CONTINUATION	$2,375,000
2021	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	4	11/19/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,503,314

Issue Date FY: 2020 ( Subtotal = $2,535,942 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	4	9/17/2020	SUPPLEMENT FOR EXPANSION	$35,942
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	4	2/14/2020	NON-COMPETING CONTINUATION	$2,500,000
														Subtotal = $2,535,942

Issue Date FY: 2019 ( Subtotal = $1,780,093 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	3	1/8/2019	NON-COMPETING CONTINUATION	$1,780,093
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	3	3/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,780,093

Issue Date FY: 2018 ( Subtotal = $1,522,341 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	2	2/22/2018	NON-COMPETING CONTINUATION	$1,522,341
														Subtotal = $1,522,341

Issue Date FY: 2017 ( Subtotal = $284,938 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	001	1	9/20/2017	NEW	$100,000
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Research Support	000	1	12/6/2016	NEW	$184,938
														Subtotal = $284,938

Grand Total All Awards = $14,736,892

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Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

Award Number: U01AR071128

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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