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Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases

Award Number: U01AI185638
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/05/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases - ABSTRACT Autoimmune or immune-mediated diseases affect 10% of the world population, and most conditions have no cure. Existing treatment options are often broadly acting and have numerous side effects. Autoimmune diseases often have a preclinical phase where a subset of symptoms occur, but they usually do not yet meet the diagnostic criteria for the disease stage. Many conditions may also have an early stage where the symptoms are milder. Early diagnosis at the preclinical phase or early disease stage is challenging as the symptoms are usually non- speciﬁc. Moreover, only a fraction of individuals will progress to disease stages, which poses challenges for clinical interventions. Understanding the genetic basis for preclinical immune-mediated diseases and dissecting risk factors that underlie the progression from preclinical to disease stage is critical. In this application, we propose to develop a series of methods and software tools to better detect genetic associations with preclinical to disease stage progressions, perform integrative genomic analysis to identify genetic signatures underlie the progression, and dissect genetic contribution to sex differences in autoimmune diseases. The methods and tools will be broadly applicable to a myriad of diseases. The proposed development received enthusiastic support from researchers studying psoriasis, Sjogren's disease, lupus, vitiligo, etc. The proposed new tools can profoundly impact the understanding the genetic basis for preclinical diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $443,830 )
2026	2026	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Allergy and Infectious Diseases Research	000	3	5/28/2026	NON-COMPETING CONTINUATION	$443,830
														Subtotal = $443,830

Issue Date FY: 2025 ( Subtotal = $443,830 )
2025	2025	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Allergy and Infectious Diseases Research	000	2	4/28/2025	NON-COMPETING CONTINUATION	$443,830
														Subtotal = $443,830

Issue Date FY: 2024 ( Subtotal = $460,680 )
2024	2024	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	Allergy and Infectious Diseases Research	000	1	7/5/2024	NEW	$460,680
														Subtotal = $460,680

Grand Total All Awards = $1,348,340

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Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases

Award Number: U01AI185638

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/05/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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