Tuesday, November 4, 2025 11/4/2025

Developing computational models to predict the immune response to B. pertussis booster vaccination

Award Number: U01AI150753
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/10/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Developing computational models to predict the immune response to B. pertussis booster vaccination - Project Summary/Abstract: Bordetella pertussis (PT) is the causative agent of whooping cough. Highly effective vaccines to protect from PT infection have been in use since the early 1940s. However, the last fifteen years have witnessed a consistent increase in the number of whooping cough cases, and the reasons for this are not completely understood. This highlights the need to better understand how immune responses against PT vary between individuals, which we can determine by measuring immune responses to PT booster vaccination as a proxy for immune responses to infectious challenge. We will use these data to develop computational models that will help establish a quantitative and predictive understanding of the factors that impact immune responses resulting from PT booster vaccination. Specifically, we will examine the impact of demographic variables such as age and sex, the type of vaccine received in infancy, and the immune state prior to vaccination. Understanding how these variables can impact vaccine responses is of importance not only for PT, but for vaccine research in general. To achieve this, we are proposing an iterative process of model building, model evaluation, experimental data generation, and model refinement. We will engage the wider scientific community in this process by hosting an annual prediction contest. We have placed particular emphasis on making this process transparent and open, to ensure that the value of the models and the results from the evaluation are accepted by the community at large. Specifically, we will: 1) Establish and seed an open platform to build and evaluate computational models of PT booster vaccination. 2) Generate new experimental data with staggered release dates to test and iteratively improve computational models. 3) Engage the broader scientific community in this modeling effort.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	7/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,350,127 )
2024	2024	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	5	5/23/2024	NON-COMPETING CONTINUATION	$135,013
2024	2024	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	2/14/2024	NON-COMPETING CONTINUATION	$1,215,114
														Subtotal = $1,350,127

Issue Date FY: 2023 ( Subtotal = $1,350,127 )
2023	2023	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	2/21/2023	NON-COMPETING CONTINUATION	$1,350,127
2023	2023	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	4	7/25/2023	NON-COMPETING CONTINUATION	$0
2023	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	3	7/25/2023	NON-COMPETING CONTINUATION	$0
2023	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	2	7/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,350,127

Issue Date FY: 2022 ( Subtotal = $1,351,458 )
2022	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	2/11/2022	NON-COMPETING CONTINUATION	$1,351,458
														Subtotal = $1,351,458

Issue Date FY: 2021 ( Subtotal = $1,350,044 )
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	3/12/2021	NON-COMPETING CONTINUATION	$1,350,044
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	2	9/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,350,044

Issue Date FY: 2020 ( Subtotal = $1,665,877 )
2020	2020	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	1	9/14/2020	SUPPLEMENT FOR EXPANSION	$274,500
2020	2020	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	3/10/2020	NEW	$1,391,377
														Subtotal = $1,665,877

Grand Total All Awards = $7,067,633

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Developing computational models to predict the immune response to B. pertussis booster vaccination

Award Number: U01AI150753

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/10/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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