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GLOBAL GAS VACCINE BASED ON THE M-PROTEIN

Award Number: U01AI060579
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2011

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GLOBAL GAS VACCINE BASED ON THE M-PROTEIN - Streptococcus pyogenes which is also known as group A streptococcus (GAS) is a Gram positive bacterial pathogen that is responsible for numerous diseases including relatively benign pharyngitis and skin infections to serious invasive diseases including necrotizing fasciitis and the post-infectious sequelae rheumatic fever, rheumatic heart disease and glomerulonephritis. Presently, there is no strategy for primary prevention that is proven to work in less-developed countries, so a vaccine is clearly needed. Some vaccine strategies under development may not be effective in less developed countries. Our long-term goal is the development of broad-spectrum global vaccine that prevents GAS infection and its associated diseases, including rheumatic fever. Our GAS vaccine candidate is based on a peptide antigen from the conserved region of the M-protein We have four potential vaccine constructs that use this antigen, each of which has shown good immunogenicity, safety and protection in pre-clinical studies. There are three overall objectives for the work in the current proposal: (1) Progression of the most advanced of our construct to clinical trials. At the conclusion of this work, we expect to have completed: (a) An initial phase I trial in adult volunteers in Australia. (b) A larger multicentre phase I trial in adult volunteers in Australia and adult volunteers in a developing country. (e) A small phase I trial in child volunteers in a developing country. (2) Further development of the conserved region peptide as an intranasal vaccine. (3) Field studies in a developing country to establish correlates of protection that may be used in phase II and III clinical trials of the conserved region peptide, and to establish a field site for these later-phase trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	000	5	11/16/2009	NON-COMPETING CONTINUATION	$0
2010	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	001	5	8/16/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	001	5	3/24/2009	NON-COMPETING CONTINUATION	$0
2009	2007	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	000	4	10/30/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $512,863 )
2008	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	000	5	8/26/2008	NON-COMPETING CONTINUATION	$512,863
														Subtotal = $512,863

Issue Date FY: 2007 ( Subtotal = $591,311 )
2007	2007	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	000	4	9/5/2007	NON-COMPETING CONTINUATION	$591,311
														Subtotal = $591,311

Issue Date FY: 2006 ( Subtotal = $599,615 )
2006	2006	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Allergy and Infectious Diseases Research	000	3	9/8/2006	NON-COMPETING CONTINUATION	$599,615
														Subtotal = $599,615

Issue Date FY: 2004 ( Subtotal = $537,966 )
2004	2004	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Microbiology and Infectious Diseases Research	000	1	9/9/2004	NEW	$537,966
														Subtotal = $537,966

Grand Total All Awards = $2,241,755

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GLOBAL GAS VACCINE BASED ON THE M-PROTEIN

Award Number: U01AI060579

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2011

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