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Skin immunity as a function of frailty, aging, and skin microbiome composition

Award Number: U01AG084765
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Skin immunity as a function of frailty, aging, and skin microbiome composition - PROJECT SUMMARY / ABSTRACT The goal of this proposal is to profile skin immunity and infection response in aging as a function of the skin microbiome. Older adults have increased susceptibility to a wide range of skin-related adverse events, including bacterial, fungal, and viral skin infections that can progress to serious systemic infection, skin cancer, and reduced quality of skin health, including skin barrier function. Different constituents of the skin microbiome modulate the development and maintenance of cutaneous innate and adaptive immunity. Physical changes in skin structure not only change the environment conducive to microbial colonization, but also changes the penetrance of its products to impact local immune function. We recently found that the skin microbiome remodeled dramatically not so much with chronological age but with frail aging, and we hypothesize that FADS interacts with cutaneous immunity to reduce skin health and responsiveness to infection. In Aim 1, we will define aging of cutaneous immunity by evaluating skin immunity, using an innovative microneedle sampling device, as a function of skin microbiome and frailty in 120 healthy younger adults, healthy older adults, and frail older adults. In Aim 2, we will use Diversity Outbred mice to model human population-level genetic diversity to investigate aging of cutaneous immunity and infection response, modeling microbial depletion, microbial colonization with healthy and frailty-associated human microbiota, and treatment with senolytics and anti- inflammatories. This work will define how the skin immune cell populations differ in aging and unhealthy aging, and how the skin microbiome differentially primes skin immunity in aging. These data provide the foundation for pinpointing influential microbes and immune interactions that may be modulated as a therapeutic or prophylactic approach, as well as identify risk factors for a range of skin disorders in older adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	1	11/20/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $512,483 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	004	2	6/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$36,514
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Aging Research	002	2	3/19/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$441,532
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	1	11/22/2024	NEW	$0
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	1	3/18/2025	NEW	-$542,000
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	003	1	4/7/2025	NEW	$11,026
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	005	1	8/6/2025	NEW	$565,411
2025	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	006	1	9/29/2025	NEW	$0
														Subtotal = $512,483

Issue Date FY: 2024 ( Subtotal = $628,891 )
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	000	1	5/24/2024	NEW	$663,328
2024	2024	JACKSON LABORATORY	600 MAIN ST	BAR HARBOR	ME	04609	HANCOCK	USA	Aging Research	001	1	7/17/2024	NEW	-$34,437
														Subtotal = $628,891

Grand Total All Awards = $1,141,374

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Skin immunity as a function of frailty, aging, and skin microbiome composition

Award Number: U01AG084765

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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