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Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging

Award Number: U01AG060906
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging - SUMMARY Aging entails a plethora of changes at multiple levels – affecting molecules, cells, tissues, organs and integrated organisms -- which culminate in a concerted decline in overall health and ultimately death. Aging is also considered a significant risk factor for many conditions and diseases, such as cardiovascular diseases (CVD), atherosclerosis, sarcopenia, osteoporosis, renal failure and neurodegenerative diseases. Whereas significant progress has been made in understanding several of the cell intrinsic molecular pathways and cellular responses that drive aging, it is very challenging to assess the progression of aging and aging-related conditions, and the field is clearly lacking robust biomarkers for aging. We propose to use our pioneering work in cellular senescence in combination with state-of-the-art proteomics technologies to develop robust senescence-related biomarkers of aging. These novel aging biomarkers are expected to become critical research tools both for transforming the way how to look at human aging and for predicting health outcomes based on biological age and not chronological age (years of age). In parallel, we will refine these biomarkers also for animal studies to gain greater insights into mechanisms of Biology of Aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1 )
2024	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	5	9/3/2024	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	5	11/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $741,606 )
2022	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	5	5/20/2022	NON-COMPETING CONTINUATION	$741,606
2022	2021	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	4	5/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $741,606

Issue Date FY: 2021 ( Subtotal = $741,606 )
2021	2021	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	4	5/11/2021	NON-COMPETING CONTINUATION	$741,606
2021	2020	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	3	11/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $741,606

Issue Date FY: 2020 ( Subtotal = $811,526 )
2020	2020	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	3	4/17/2020	NON-COMPETING CONTINUATION	$811,526
2020	2019	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	2	1/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $811,526

Issue Date FY: 2019 ( Subtotal = $892,662 )
2019	2019	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	002	2	9/6/2019	SUPPLEMENT FOR EXPANSION	$151,056
2019	2019	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	2	4/3/2019	NON-COMPETING CONTINUATION	$741,606
2019	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	1	2/21/2019	NEW	$0
														Subtotal = $892,662

Issue Date FY: 2018 ( Subtotal = $765,106 )
2018	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	1	9/17/2018	NEW	$765,106
														Subtotal = $765,106

Grand Total All Awards = $3,952,505

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Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging

Award Number: U01AG060906

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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