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Caenorhabditis Intervention Testing Program at Oregon

Award Number: U01AG045829
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2013
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Caenorhabditis Intervention Testing Program at Oregon - Caenorhabditis Intervention Testing Program Renewal at Oregon—Project Summary Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animal models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The goal of the proposed work is to continue, and expand, efforts of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. A specific emphasis of this integrated super-group is to test promising compound on a collection of natural variants of the Caenorhabditis genus, which together represent the extensive genetic heterogeneity in the human population. The idea is that treatments that confer positive outcomes across a diverse population will have an increased chance of being effective in humans. The emphasis of this specific proposal is to capitalize upon the very high temporal resolution provided by our automated lifespan approach to expand upon our existing analytical framework to include an analysis of variation in rates of aging using more general statistical models that allow for changes in the rate of mortality over an individual’s lifespan. This approach provides a unique hypothesis testing framework that is particularly well suited for compound interventions. In addition, we will build upon our translational capacity by using RNA- seq to identify genetic pathways targeted by longevity-extending compounds and to understand which molecular systems maintain early-life function later in life as a hallmark of healthy aging. Mapping these changes onto known mammalian genetic regulatory systems will allow us to determine which interventions are most likely to serve as targets for rapid translation. Overall, we will participate in a unique team project that has the power to define pharmacological interventions that robustly promote strong healthspan across a varied population, with implications for development of therapies that promote healthy human aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $579,091 )
2025	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	12	7/29/2025	NON-COMPETING CONTINUATION	$579,091
														Subtotal = $579,091

Issue Date FY: 2024 ( Subtotal = $590,910 )
2024	2024	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	11	6/28/2024	NON-COMPETING CONTINUATION	$590,910
2024	2023	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	10	3/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $590,910

Issue Date FY: 2023 ( Subtotal = $590,910 )
2023	2023	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	10	8/1/2023	NON-COMPETING CONTINUATION	$590,910
2023	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	9	7/10/2023	COMPETING CONTINUATION	$122,442
2023	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	8	7/10/2023	SUPPLEMENT FOR EXPANSION	-$122,442
														Subtotal = $590,910

Issue Date FY: 2022 ( Subtotal = $838,601 )
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	8	5/20/2022	SUPPLEMENT FOR EXPANSION	$247,691
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	003	9	7/22/2022	COMPETING CONTINUATION	$590,910
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	8	7/21/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	8	7/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $838,601

Issue Date FY: 2021 ( Subtotal = $550,719 )
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	8	3/19/2021	NON-COMPETING CONTINUATION	$550,719
2021	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	7	11/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $550,719

Issue Date FY: 2020 ( Subtotal = $550,719 )
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	7	4/14/2020	NON-COMPETING CONTINUATION	$550,719
2020	2019	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	6	1/8/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $550,719

Issue Date FY: 2019 ( Subtotal = $968,314 )
2019	2019	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	6	6/5/2019	SUPPLEMENT FOR EXPANSION	$290,823
2019	2019	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	6	3/21/2019	NON-COMPETING CONTINUATION	$677,491
2019	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	5	11/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $968,314

Issue Date FY: 2018 ( Subtotal = $677,491 )
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	5	9/13/2018	SUPPLEMENT FOR EXPANSION	$126,772
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	5	4/18/2018	NON-COMPETING CONTINUATION	$550,719
														Subtotal = $677,491

Issue Date FY: 2017 ( Subtotal = $549,786 )
2017	2017	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	007	4	9/26/2017	COMPETING CONTINUATION	$35,181
2017	2017	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	004	4	8/4/2017	COMPETING CONTINUATION	$549,786
2017	2017	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	4	4/4/2017	COMPETING CONTINUATION	$549,786
2017	2017	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	003	4	8/1/2017	COMPETING CONTINUATION	-$549,786
2017	2016	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	006	3	9/26/2017	SUPPLEMENT FOR EXPANSION	-$35,181
2017	2016	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	3	6/1/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2015	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	005	3	9/26/2017	NON-COMPETING CONTINUATION	$0
2017	2015	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	3	6/1/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $549,786

Issue Date FY: 2016 ( Subtotal = $284,894 )
2016	2016	UNIVERSITY OF OREGON	POST OFFICE BOX 3237	EUGENE	OR	97403	LANE	USA	Aging Research	000	3	7/14/2016	SUPPLEMENT FOR EXPANSION	$284,894
														Subtotal = $284,894

Issue Date FY: 2015 ( Subtotal = $401,538 )
2015	2015	UNIVERSITY OF OREGON	POST OFFICE BOX 3237	EUGENE	OR	97403	LANE	USA	Aging Research	000	3	8/4/2015	NON-COMPETING CONTINUATION	$401,538
														Subtotal = $401,538

Issue Date FY: 2014 ( Subtotal = $422,634 )
2014	2014	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Aging Research	000	2	6/3/2014	NON-COMPETING CONTINUATION	$422,634
														Subtotal = $422,634

Issue Date FY: 2013 ( Subtotal = $428,594 )
2013	2013	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Aging Research	000	1	8/7/2013	NEW	$428,594
														Subtotal = $428,594

Grand Total All Awards = $7,434,201

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Caenorhabditis Intervention Testing Program at Oregon

Award Number: U01AG045829

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2013

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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