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Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical Center

Award Number: U01AG018947
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

¿ DESCRIPTION (provided by applicant): Knee osteoarthritis (OA) is a common chronic painful disorder that is the most frequent cause of mobility disability in older people. The MOST study has been a major source of new knowledge about the course of this disease and factors that affect its course. Since the study began in 2003, it is increasingly recognized that by the time people develop chronic symptoms of knee OA, they usually have advanced structural findings of disease on MRI. Findings such as meniscal tears, malalignment and cartilage loss drive further structural deterioration and almost certainly limit prevention opportunities. We believe that prevention opportunities are likely to be greater if started in those who do not yet have severe continuous knee pain or advanced structural findings of disease. The functional impacts of knee OA occur in older people who experience multiple musculoskeletal comorbidities, and preventing disablement from OA requires a broader perspective than a focus on a single knee. For example, those with pain in one knee are at high risk of pain in other lower extremity musculoskeletal regions and, even if the knee is replaced, they may ultimately need treatment for pain in other joints developing as a consequence of the first joint affected. Also, in additionto functional loss, persons with OA experience buckling, falls and constraints in their involvement with the outside environment. We suggest there are opportunities to develop treatments and disease prevention strategies that have been unexplored and that by using new technologies and focusing on persons at a milder or earlier disease stage than previous studies, we can identify such opportunities. We propose to recruit a new mild disease cohort and continue to study the existing MOST cohort to identify new risk factors for disease and to study consequences of disease. Our goal is to find new strategies to prevent disease at an early stage and to limit the impact of disease once it has occurred.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$323,296 )
2023	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	18	4/20/2023	SUPPLEMENT FOR EXPANSION	-$59,442
2023	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	18	4/20/2023	NON-COMPETING CONTINUATION	-$263,854
2023	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	17	2/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = -$323,296

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	18	11/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	18	7/19/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	18	7/19/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $59,442 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	18	9/9/2020	SUPPLEMENT FOR EXPANSION	$59,442
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	18	4/14/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	18	8/6/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $59,442

Issue Date FY: 2019 ( Subtotal = $276,166 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	18	5/15/2019	NON-COMPETING CONTINUATION	$276,166
														Subtotal = $276,166

Issue Date FY: 2018 ( Subtotal = $1,029,361 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	17	6/7/2018	NON-COMPETING CONTINUATION	$1,029,361
														Subtotal = $1,029,361

Issue Date FY: 2017 ( Subtotal = $995,460 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	16	7/4/2017	NON-COMPETING CONTINUATION	$995,460
														Subtotal = $995,460

Issue Date FY: 2016 ( Subtotal = $1,859,443 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	15	5/23/2016	NON-COMPETING CONTINUATION	$1,740,999
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	15	8/31/2016	SUPPLEMENT FOR EXPANSION	$118,444
														Subtotal = $1,859,443

Issue Date FY: 2015 ( Subtotal = $2,010,192 )
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	14	6/24/2015	COMPETING CONTINUATION	$2,010,192
2015	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	13	6/22/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,010,192

Issue Date FY: 2014 ( Subtotal = $113,411 )
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	13	2/14/2014	NON-COMPETING CONTINUATION	$11,341
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	13	1/23/2014	NON-COMPETING CONTINUATION	$102,070
														Subtotal = $113,411

Issue Date FY: 2013 ( Subtotal = $112,185 )
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	12	5/15/2013	NON-COMPETING CONTINUATION	$5,342
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	12	12/20/2012	NON-COMPETING CONTINUATION	$106,843
														Subtotal = $112,185

Issue Date FY: 2012 ( Subtotal = $743,500 )
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	11	12/30/2011	NON-COMPETING CONTINUATION	$681,093
2012	2012	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	11	2/1/2012	NON-COMPETING CONTINUATION	$62,407
														Subtotal = $743,500

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2010	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	10	7/28/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $786,567 )
2010	2010	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	10	7/14/2010	NON-COMPETING CONTINUATION	$786,567
2010	2009	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	9	2/8/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $786,567

Issue Date FY: 2009 ( Subtotal = $973,319 )
2009	2009	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	9	7/8/2009	NON-COMPETING CONTINUATION	$973,319
														Subtotal = $973,319

Issue Date FY: 2008 ( Subtotal = $1,166,880 )
2008	2008	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	8	9/12/2008	COMPETING CONTINUATION	$1,166,880
														Subtotal = $1,166,880

Issue Date FY: 2007 ( Subtotal = $88,162 )
2007	2007	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	7	7/24/2007	NON-COMPETING CONTINUATION	$88,162
														Subtotal = $88,162

Issue Date FY: 2006 ( Subtotal = $249,258 )
2006	2006	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	6	8/21/2006	SUPPLEMENT FOR EXPANSION	$34,655
2006	2006	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	6	8/14/2006	NON-COMPETING CONTINUATION	$214,603
														Subtotal = $249,258

Issue Date FY: 2004 ( Subtotal = $394,489 )
2004	2004	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	4	7/12/2004	NON-COMPETING CONTINUATION	$394,489
														Subtotal = $394,489

Grand Total All Awards = $12,500,925

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Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical Center

Award Number: U01AG018947

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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