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4/8: INIA Stress and Chronic Alcohol Interactions: Impact of stress mediated locus coeruleus dysregulation on cognitive control and excessive drinking

Award Number: U01AA025481
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY/ABSTRACT There is strong comorbidity between alcohol use disorders and chronic stress and anxiety. Dysfunction within overlapping neural targets of alcohol and stress may facilitate the development of this comorbid phenotype. The locus coeruleus norepinephrine (LC-NE) system is sensitive to both alcohol and stress and plays an important role in cognitive and emotional regulation of behavior. Plasticity within LC-NE circuits after chronic stress and alcohol can produce feed-forward effects, elevating stress and anxiety via the HPA axis and decreasing cognitive control by disrupting prefrontal cortex (PFC) function. The consequence of this stress- cognition “double-hit” is an increased need to drink and a decreased control over drinking. Our preliminary evidence demonstrates that chronic intermittent ethanol exposure in addition to repeated swim stress, disrupts PFC dependent cognition and increases excessive drinking more than either ethanol or stress alone. In these studies we will investigate the LC as a key target of stress/ethanol maladaptations and the potential for LC-NE targeted therapeutics to ameliorate stress/ethanol induced executive dysfunction, elevated anxiety, and excessive drinking. This project will provide new insights into the role of LC-NE dysfunction after chronic stress and alcohol. Our results will identify novel circuit changes underlying excessive alcohol consumption and the potential for NE targeted therapies in treating cognitive and emotional dysfunction in alcohol use disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $414,763 )
2024	2024	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	8	1/18/2024	NON-COMPETING CONTINUATION	$414,763
														Subtotal = $414,763

Issue Date FY: 2023 ( Subtotal = $465,254 )
2023	2023	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	7	2/2/2023	NON-COMPETING CONTINUATION	$465,254
														Subtotal = $465,254

Issue Date FY: 2022 ( Subtotal = $446,161 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	006	6	6/15/2022	COMPETING CONTINUATION	$249,728
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	001	6	2/16/2022	COMPETING CONTINUATION	$446,161
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	007	6	8/25/2022	COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	002	6	3/22/2022	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	005	5	6/15/2022	SUPPLEMENT FOR EXPANSION	-$249,728
2022	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	004	5	5/13/2022	NON-COMPETING CONTINUATION	$0
2022	2020	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	003	4	4/26/2022	NON-COMPETING CONTINUATION	$0
2022	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	3	11/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $446,161

Issue Date FY: 2021 ( Subtotal = $632,946 )
2021	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	001	5	4/13/2021	SUPPLEMENT FOR EXPANSION	$313,946
2021	2021	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	5	2/18/2021	NON-COMPETING CONTINUATION	$319,000
														Subtotal = $632,946

Issue Date FY: 2020 ( Subtotal = $319,000 )
2020	2020	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	4	2/17/2020	NON-COMPETING CONTINUATION	$319,000
														Subtotal = $319,000

Issue Date FY: 2019 ( Subtotal = $319,000 )
2019	2019	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	3	1/30/2019	NON-COMPETING CONTINUATION	$319,000
														Subtotal = $319,000

Issue Date FY: 2018 ( Subtotal = $319,000 )
2018	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	2	1/24/2018	NON-COMPETING CONTINUATION	$287,100
2018	2018	UNIVERSITY OF MASSACHUSETTS	COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	001	2	5/21/2018	NON-COMPETING CONTINUATION	$31,900
														Subtotal = $319,000

Issue Date FY: 2017 ( Subtotal = $319,000 )
2017	2017	UNIVERSITY OF MASSACHUSETTS	70 BUTTERFIELD TERRACE	AMHERST	MA	01003	HAMPSHIRE	USA	Alcohol Research Programs	000	1	2/1/2017	NEW	$319,000
														Subtotal = $319,000

Grand Total All Awards = $3,235,124

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4/8: INIA Stress and Chronic Alcohol Interactions: Impact of stress mediated locus coeruleus dysregulation on cognitive control and excessive drinking

Award Number: U01AA025481

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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