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5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions

Award Number: U01AA020911
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions - Project Summary In this project we will mechanistically explore two neuromodulatory systems within the extended amydala and how they regulate plasticity and behavior following alcohol exposure and stress. In particular, in aims 1 and 2 we will utilize novel CRISPR technology to manipulate signaling in discrete brain regions, building on our prior investigations. In aim 1, we will explore the role of central amygdala (CeA) Kappa Opioid Receptor (KOR) signaling in alcohol and stress driven alterations in plasticity and in vivo dynamics of specific bed nucleus of the stria terminalis (BNST) outputs. In aim 2, we will investigate the contribution of noradrenergic signaling to alcohol drinking and alcohol driven disruptions of behavior. In aim 3, we will collaborate within and across INIA consortia in three ways (i.) investigating how CeA KOR knock out regulates alcohol exposure induced disruptions of dopamine signaling in vivo (Jones/Holleran component) , (ii.) investigating adrenergic receptor modulation in the BNST following alcohol consumption (Grant/Schnitko), (iii.) whole brain cFos analysis following GPR88 agonism to reduce alcohol consumption (Kieffer/Harsan). Thus, these integrated, yet independent aims, will provide circuit specific mechanistic findings in critical nodes that have been established to contribute to multiple aspects of the positive and negative reinforcing properties of alcohol.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $403,841 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	14	3/5/2025	NON-COMPETING CONTINUATION	$403,841
														Subtotal = $403,841

Issue Date FY: 2024 ( Subtotal = $448,712 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	13	1/18/2024	NON-COMPETING CONTINUATION	$403,841
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	13	5/16/2024	NON-COMPETING CONTINUATION	$44,871
														Subtotal = $448,712

Issue Date FY: 2023 ( Subtotal = $448,712 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	12	2/1/2023	NON-COMPETING CONTINUATION	$448,712
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	11	5/25/2023	COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	10	5/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $448,712

Issue Date FY: 2022 ( Subtotal = $462,587 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	003	11	5/9/2022	COMPETING CONTINUATION	$21,166
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	11	2/16/2022	COMPETING CONTINUATION	$462,587
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	11	3/22/2022	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	10	5/9/2022	NON-COMPETING CONTINUATION	-$21,166
														Subtotal = $462,587

Issue Date FY: 2021 ( Subtotal = $447,515 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	10	2/15/2021	NON-COMPETING CONTINUATION	$447,515
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	9	1/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $447,515

Issue Date FY: 2020 ( Subtotal = $491,235 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	9	1/30/2020	NON-COMPETING CONTINUATION	$491,235
														Subtotal = $491,235

Issue Date FY: 2019 ( Subtotal = $810,375 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	8	9/18/2019	SUPPLEMENT FOR EXPANSION	$42,465
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	8	1/29/2019	NON-COMPETING CONTINUATION	$380,000
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	8	9/4/2019	SUPPLEMENT FOR EXPANSION	$387,910
														Subtotal = $810,375

Issue Date FY: 2018 ( Subtotal = $480,000 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	7	1/17/2018	NON-COMPETING CONTINUATION	$341,999
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	7	8/24/2018	SUPPLEMENT FOR EXPANSION	$100,000
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	7	5/22/2018	NON-COMPETING CONTINUATION	$38,001
														Subtotal = $480,000

Issue Date FY: 2017 ( Subtotal = $380,000 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	002	6	5/15/2017	COMPETING CONTINUATION	$748
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	6	1/31/2017	COMPETING CONTINUATION	$380,000
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	5	5/15/2017	EXTENSION WITH OR WITHOUT FUNDS	-$748
														Subtotal = $380,000

Issue Date FY: 2016 ( Subtotal = $185,000 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	5	1/26/2016	EXTENSION WITH OR WITHOUT FUNDS	$185,000
														Subtotal = $185,000

Issue Date FY: 2015 ( Subtotal = $179,449 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	4	1/26/2015	NON-COMPETING CONTINUATION	$179,449
														Subtotal = $179,449

Issue Date FY: 2014 ( Subtotal = $179,449 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	3	1/10/2014	NON-COMPETING CONTINUATION	$166,500
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	3	3/5/2014	NON-COMPETING CONTINUATION	$12,949
														Subtotal = $179,449

Issue Date FY: 2013 ( Subtotal = $172,050 )
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	001	2	6/5/2013	NON-COMPETING CONTINUATION	$5,550
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	2	1/21/2013	NON-COMPETING CONTINUATION	$166,500
														Subtotal = $172,050

Issue Date FY: 2012 ( Subtotal = $185,000 )
2012	2012	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Alcohol Research Programs	000	1	2/9/2012	NEW	$185,000
														Subtotal = $185,000

Grand Total All Awards = $5,273,925

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5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions

Award Number: U01AA020911

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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