Monday, August 18, 2025 8/18/2025

1/8 NADIA U01 Effects of Adolescent Alcohol Exposure on Hippocampal Function in Adulthood

Award Number: U01AA019925
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2010
PERIOD OF PERFORMANCE END DATE: 09/07/2024

Group Awards By:

View Award Description

1/8 NADIA U01 Effects of Adolescent Alcohol Exposure on Hippocampal Function in Adulthood - The NADIA consortium is dedicated to identifying the mechanisms underlying the long-term effects of adolescent intermittent ethanol exposure (AIE) on brain and behavior and exploring approaches to prevent or reverse them. Component 1 has focused on the enduring effects of AIE on hippocampal structure and function and their behavioral sequelae. Based on our findings, our overarching hypothesis AIE causes an enduring but reversible compromise of hippocampal synaptic function driven by interacting epigenetic, neuroinflammatory, and glial mechanisms. During the last NADIA funding cycle we found that AIE produces a pro-inflammatory milieu in the hippocampal formation, alterations of dendritic spine density and morphology, altered histone acetylation and methylation, diminished astrocyte-synaptic proximity, decreases in neurogenesis, and increases in the mobilization cell death molecular machinery. Through NADIA collaborations, we further identified epigenetic changes that suggest specific molecular mechanisms underlying those effects. Importantly, we have also shown that many of those effects are reversible in adulthood with pharmacological agents in current clinical use. Our recent findings indicate that AIE results in a propensity toward anxiety-like behavior after environmental challenge, thus suggesting the need to expand our assessments to the ventral hippocampus. This has obvious translational implications because anxiety and stress reactivity are strong predictors of AUD development and relapse, and suggests that some of the AIE-induced changes we have observed in the dorsal hippocampus may be similar in the ventral region. Against this backdrop we propose three Specific Aims that will more fully characterize the AIE-induced phenotypes we have identified, identify mechanisms underlying them, and explore treatments to reverse them. Aim 1 will address the role of histone H3K27 acetylation, and other possible molecular mechanisms, in AIE- induced dendritic spine changes, and further characterize our previously-reported reversal of AIE-induced spine changes by donepezil. Aim 2 will follow-up our recent findings to identify mechanisms underlying AIE- induced induction of hippocampal inflammatory markers and corresponding reductions of neurogenesis and increased cell death cascade markers. Aim 3 is founded on preliminary data indicating that AIE causes a decrease in astrocyte-synaptic proximity that could be of functional synaptic significance. We will confirm and expand that finding, and assess its pharmacological reversibility in adulthood. Our goal is to explore possible interlacing mechanisms underlying AIE effects on synaptic, inflammatory, and glial function. These proposed studies are all based on distinct sets of preliminary data, will address specific epigenetic and molecular mechanisms underlying AIE effects on hippocampal structure and function, and will expand our understanding of translationally-relevant AIE-induced phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$17,097 )
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	003	15	6/9/2025	NON-COMPETING CONTINUATION	-$14,319
2025	2024	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Alcohol Research Programs	001	16	5/9/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$381,681
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	000	15	5/9/2025	NON-COMPETING CONTINUATION	-$381,681
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	002	14	6/9/2025	NON-COMPETING CONTINUATION	-$2,778
														Subtotal = -$17,097

Issue Date FY: 2024 ( Subtotal = $396,000 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	001	15	8/14/2024	NON-COMPETING CONTINUATION	$396,000
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	000	14	7/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $396,000

Issue Date FY: 2023 ( Subtotal = $396,000 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	000	14	8/15/2023	NON-COMPETING CONTINUATION	$396,000
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Alcohol Research Programs	001	13	8/17/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $396,000

Issue Date FY: 2022 ( Subtotal = $445,502 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	13	8/25/2022	NON-COMPETING CONTINUATION	$396,000
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	001	13	8/26/2022	SUPPLEMENT FOR EXPANSION	$49,502
														Subtotal = $445,502

Issue Date FY: 2021 ( Subtotal = $621,556 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	003	12	8/26/2021	SUPPLEMENT FOR EXPANSION	$160,804
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	002	12	8/23/2021	NON-COMPETING CONTINUATION	$396,000
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	004	12	8/27/2021	SUPPLEMENT FOR EXPANSION	$64,752
2021	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	001	11	1/30/2021	COMPETING CONTINUATION	$130,955
2021	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	10	1/30/2021	NON-COMPETING CONTINUATION	-$130,955
														Subtotal = $621,556

Issue Date FY: 2020 ( Subtotal = $411,250 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	001	11	7/31/2020	COMPETING CONTINUATION	$411,250
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	002	11	9/15/2020	COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	10	3/20/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $411,250

Issue Date FY: 2019 ( Subtotal = $357,750 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	10	8/2/2019	NON-COMPETING CONTINUATION	$357,750
														Subtotal = $357,750

Issue Date FY: 2018 ( Subtotal = $357,750 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	9	8/23/2018	NON-COMPETING CONTINUATION	$357,750
														Subtotal = $357,750

Issue Date FY: 2017 ( Subtotal = $357,750 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	8	8/18/2017	NON-COMPETING CONTINUATION	$357,750
														Subtotal = $357,750

Issue Date FY: 2016 ( Subtotal = $289,125 )
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	7	7/27/2016	NON-COMPETING CONTINUATION	$289,125
														Subtotal = $289,125

Issue Date FY: 2015 ( Subtotal = $289,125 )
2015	2015	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	6	8/27/2015	COMPETING CONTINUATION	$289,125
														Subtotal = $289,125

Issue Date FY: 2014 ( Subtotal = $287,931 )
2014	2014	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	5	7/31/2014	NON-COMPETING CONTINUATION	$287,931
														Subtotal = $287,931

Issue Date FY: 2013 ( Subtotal = $276,058 )
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	4	7/24/2013	NON-COMPETING CONTINUATION	$276,058
														Subtotal = $276,058

Issue Date FY: 2012 ( Subtotal = $296,836 )
2012	2012	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	3	8/7/2012	NON-COMPETING CONTINUATION	$296,836
														Subtotal = $296,836

Issue Date FY: 2011 ( Subtotal = $297,710 )
2011	2011	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	2	8/12/2011	NON-COMPETING CONTINUATION	$297,710
														Subtotal = $297,710

Issue Date FY: 2010 ( Subtotal = $306,664 )
2010	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Alcohol Research Programs	000	1	9/1/2010	NEW	$306,664
														Subtotal = $306,664

Grand Total All Awards = $5,369,910

Top

All Categories

About

Search

Reports

Data Submission

Award Information

1/8 NADIA U01 Effects of Adolescent Alcohol Exposure on Hippocampal Function in Adulthood

Award Number: U01AA019925

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2010

PERIOD OF PERFORMANCE END DATE: 09/07/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer