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Whole Body Effects of PAE Across the Life Span: Early Markers of & Clinical Interventions for Children and Adolescents in Ukraine

Award Number: U01AA014835
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Numerous comorbidities have been identified as relatively common among children and adolescents with prenatal alcohol exposure (PAE) or fetal alcohol spectrum disorders (FASDs) including sleep disturbances, hypertension, abnormal eating behaviors, altered growth patterns, and comorbid depression and anxiety. In addition, emerging data suggest that several adult diseases of developmental origin, such as diabetes, atherosclerosis, cardiovascular and autoimmune disorders are over-represented and have earlier age at onset in adults with FASDs. It is imperative to better understand the prevalence and co-occurrence of these disorders as early as possible in the life course of children and adolescents with PAE, ideally at the sub-clinical stage, in order to intervene in clinically meaningful ways. Building on the existing Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) longitudinal cohort study in Ukraine, we aim to fill this critical gap in knowledge in two ways. First, we will compare the prevalence and characteristics of subclinical and clinical signs/symptoms of current and developing metabolic and other chronic diseases and contributing factors in 180 children/adolescents with PAE age-matched to 120 children/adolescents with no/minimal PAE. This includes comparing prevalence of premorbid or comorbid hypertension, hyperlipidemia, impaired glucose tolerance/insulin resistance, and cardiovascular disease and also comparing growth parameters, physical activity, dietary intake, adverse childhood experiences, sleep disturbances, and measures of anxiety and depression. Second, we will compare findings on a panel of experimental measures of structure or function that can help illuminate mechanisms of PAE-related comorbidities across the lifespan in the same cohort of 300 children and adolescents. Experimental measures include capillary microvasculature, telomere length, and patterns of miRNA expression. Findings that are actionable will translate on the individual level to clinical guidance provided to the participant and caregiver. Furthermore, in keeping with one of the primary goals of CIFASD5, findings of this study will directly inform future intervention targets in children and adolescents to help remediate, ameliorate or prevent progression of pre-clinical or clinical conditions identified in the study evaluations. We will also work collaboratively with other investigators in the CIFASD Consortium to interactively address the overall goals of the Consortium in improving diagnosis and treatment of FASD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	21	11/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $544,674 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	21	5/10/2024	NON-COMPETING CONTINUATION	$544,674
														Subtotal = $544,674

Issue Date FY: 2023 ( Subtotal = $525,964 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	20	5/10/2023	NON-COMPETING CONTINUATION	$525,964
2023	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	18	5/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $525,964

Issue Date FY: 2022 ( Subtotal = $497,196 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	19	8/11/2022	COMPETING CONTINUATION	$497,196
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	18	12/6/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $497,196

Issue Date FY: 2021 ( Subtotal = $357,381 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	18	5/31/2021	NON-COMPETING CONTINUATION	$357,381
														Subtotal = $357,381

Issue Date FY: 2020 ( Subtotal = $360,729 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	17	5/21/2020	NON-COMPETING CONTINUATION	$360,729
														Subtotal = $360,729

Issue Date FY: 2019 ( Subtotal = $460,729 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	16	6/3/2019	NON-COMPETING CONTINUATION	$460,729
2019	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	15	12/14/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $460,729

Issue Date FY: 2018 ( Subtotal = $432,784 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	15	5/16/2018	NON-COMPETING CONTINUATION	$332,784
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	15	9/3/2018	SUPPLEMENT FOR EXPANSION	$100,000
														Subtotal = $432,784

Issue Date FY: 2017 ( Subtotal = $373,182 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	003	14	7/6/2017	COMPETING CONTINUATION	$373,182
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	13	12/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$219,770
2017	2016	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	004	13	9/14/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2015	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	002	12	12/1/2016	SUPPLEMENT FOR EXPANSION	-$49,644
2017	2015	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	12	12/1/2016	NON-COMPETING CONTINUATION	-$170,126
														Subtotal = $373,182

Issue Date FY: 2016 ( Subtotal = $703,619 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	13	5/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$703,619
														Subtotal = $703,619

Issue Date FY: 2015 ( Subtotal = $780,562 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	12	9/3/2015	SUPPLEMENT FOR EXPANSION	$49,644
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	12	5/4/2015	NON-COMPETING CONTINUATION	$730,918
														Subtotal = $780,562

Issue Date FY: 2014 ( Subtotal = $733,480 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	11	6/17/2014	NON-COMPETING CONTINUATION	$733,480
														Subtotal = $733,480

Issue Date FY: 2013 ( Subtotal = $707,993 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	001	10	7/3/2013	NON-COMPETING CONTINUATION	$0
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	10	6/5/2013	NON-COMPETING CONTINUATION	$707,993
														Subtotal = $707,993

Issue Date FY: 2012 ( Subtotal = $712,950 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	9	8/9/2012	COMPETING CONTINUATION	$712,950
														Subtotal = $712,950

Issue Date FY: 2011 ( Subtotal = $521,526 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	8	7/22/2011	NON-COMPETING CONTINUATION	$521,526
														Subtotal = $521,526

Issue Date FY: 2010 ( Subtotal = $579,374 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	7	8/3/2010	NON-COMPETING CONTINUATION	$579,374
														Subtotal = $579,374

Issue Date FY: 2009 ( Subtotal = $630,076 )
2009	2009	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	6	7/21/2009	NON-COMPETING CONTINUATION	$630,076
														Subtotal = $630,076

Issue Date FY: 2008 ( Subtotal = $690,277 )
2008	2008	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	5	8/1/2008	NON-COMPETING CONTINUATION	$690,277
														Subtotal = $690,277

Issue Date FY: 2007 ( Subtotal = $656,344 )
2007	2007	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	4	9/29/2007	COMPETING CONTINUATION	$656,344
														Subtotal = $656,344

Issue Date FY: 2004 ( Subtotal = $254,448 )
2004	2004	UNIVERSITY OF CALIFORNIA-SAN DIEGO	Q027	LA JOLLA	CA	92093	SAN DIEGO	USA	Alcohol Research Programs	000	2	8/23/2004	NON-COMPETING CONTINUATION	$254,448
														Subtotal = $254,448

Grand Total All Awards = $10,742,225

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Whole Body Effects of PAE Across the Life Span: Early Markers of & Clinical Interventions for Children and Adolescents in Ukraine

Award Number: U01AA014835

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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