Friday, May 9, 2025
5/9/2025
Washington University Institute of Clinical and Translational Sciences (TL1) - Contact PD/PI: Powderly, William G. NRSA-Training-001 (075) J. NRSA Training Core (TL1), 7. Project Summary/Abstract Washington University School of Medicine has a robust research infrastructure, outstanding faculty mentors, well-developed clinical and translational research (CTR) training programs, and a large and diverse pool of excellent pre- and postdoctoral candidates. The objective of the TL1 is to ignite an interest in becoming a CTR scientist and provide the research experience, coursework, and career development opportunities to achieve this goal. Over the past 15 years, the TL1 has successfully trained predoctoral MD, PhD, and allied health doctoral students. For our last competitive renewal, we added postdoctoral trainees interested in entrepreneurship, technology transfer, and intellectual property development. We now propose to expand our program to add support for a mentored career development pathway for MD clinical fellows. We describe new innovative curricula in biomedical informatics, dissemination and implementation (D&I) science, community engagement, team science, health equity, and online initiatives. We will introduce new mentor training programs coordinated by the Clinical Research Training Center. We request annual funding for 5 predoctoral and 7 postdoctoral trainees for 1-2 years. The overall aims of the TL1 Program are: Aim 1: Enhance TL1 infrastructure and programs to provide outstanding clinical and translational research training opportunities for predoctoral and postdoctoral trainees. Aim 2: Develop competency-based, personalized learning opportunities for diverse trainees focused on conducting and integrating translational research in populations and across the lifespan. Aim 3: Engage diverse trainees, community stakeholders in multidisciplinary collaborative clinical and translational research to accelerate the benefit and impact of translational science. Aim 4: Provide high–quality comprehensive informatics training. Aim 5: Perform robust tracking and evaluation of TL1 program, trainees, and alumni, and use these data to improve the TL1 program. Trainees will engage in a mentored research experience with one of 74 experienced program faculty, complete CTR coursework, and engage in career development activities. This award period will focus on expanding training opportunities and increase recruitment of trainees from diverse backgrounds. The TL1 Program fills a critical niche at WUSM and our partners through its multidisciplinary focus on clinical and translational research, and unique emphasis on entrepreneurship, D&I, community engagement, and health equity. We will also work with the CTSA consortium to share curriculum, training, career development programs, and methods and tools to continually improve and provide outstanding CTR training in the future. Project Summary/Abstract Page 1517 Contact PD/PI: Powderly, William G. NRSA-Training-001 (075) J. NRSA Training Core (TL1) 9. Bibliography and References Cited 1. https://clic-ctsa.org/news/insights-inspire-making-commitment-diversity-inclusion. 2. Bastian M, Heymann S, Jacomy M. Gephi: An Open Source Software for Exploring and Manipulating Networks. Proceedings of the International AAAI Conference on Web and Social Media. 2009 03/19;3(1). 3. Abedin Z, Biskup E, Silet K, Garbutt JM, Kroenke K, Feldman MD, McGee R, Jr., Fleming M, Pincus HA. Deriving competencies for mentors of clinical and translational scholars. Clin Transl Sci. 2012 Jun;5(3):273-80. PMCID: PMC3476465. 4. Keyser DJ, Lakoski JM, Lara-Cinisomo S, Schultz DJ, Williams VL, Zellers DF, Pincus HA. Advancing institutional efforts to support research mentorship: a conceptual framework and self-assessment tool. Acad Med. 2008 Mar;83(3):217-25. 5. https://cimerproject.org/entering-mentoring/ 6. Meagher E, Taylor L, Probsfield J, Fleming M. Evaluating research mentors working in the area of clinical translational science: a review of the literature. Clin Transl Sci. 2011 Oct;4(5):353-
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