This is a new application for an Interdisciplinary Pulmonary Training Program T32, the Duke Program of Training
in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER), submitted under
a multiple PI plan. This program provides the opportunity for diverse, exceptional postdoctoral MD and PhD
trainees to acquire state-of-the-art knowledge and research skills in independent investigation into the
pathogenesis, treatments and outcomes of lung diseases. PROSPER is a fresh start for a program that has been
centered in the Division of Pulmonary, Allergy and Critical Care Medicine at Duke University for 36 years and
founded on basic and clinical biomedical research approaches. PROSPER includes carefully selected,
exceptional senior mentors from the Department of Medicine and Departments of Biostatistics, Bioengineering,
Cell Biology, Pathology, Population Health Sciences, Psychiatry, Surgery, and the School of the Environment.
We also include early career scientists to serve as emerging mentors to provide our trainees with most relevant,
clinically- and scientifically-sound mentorship. Over the last 15 years, nearly 75% of our trainees continued in
research-oriented careers, and many of them became independently funded pulmonary scientists. Prior
successes notwithstanding, we identified critical areas for improvement, as a result of which we propose this
new program with expanded recruitment efforts to attract talented PhD trainees, in addition to typical MD
trainees, from relevant graduate schools at Duke and other leading universities. In addition, in PROSPER, we
commit to increasing diversity of our trainees, thus began making concerted efforts in recruitment and retention
of trainees from underrepresented minority backgrounds. We establish formal Internal and External Advisory
Boards, comprised of experienced Duke mentors and leading pulmonary scientists, and create a formal review
and feedback structure, which includes perspectives of internal advisors, external advisors, trainees, and the
NIH program officers. We establish rigorous accountability structures for the development of research, academic
career, and scholarship skills. These requirements include: to establish a mentoring committee, to create an
individual development plan, to conduct rigorous research project(s), to write and submit several manuscripts,
to present at professional gatherings, and to draft an individual career development grant by the conclusion of
training. Each trainee will also participate in a structured didactic training program, including formal coursework,
divisional seminars, lectures from distinguished invited speakers, and career development workshops designed
to expand and deepen trainees’ scientific background. Our goal is to prepare the next generation of pulmonary
scientists by providing each trainee with an individualized system of supports, which include thoughtful
mentorship, research experience, didactic learning, career development skills, scholarship, and networking, so
they can successfully establish research careers and obtain independent funding in a highly competitive
environment.