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Global Cardiometabolic Disease Training

Award Number: T32HL129969
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Global Cardiometabolic Disease Training - Abstract We propose to renew our global cardiometabolic disease (GCMD) predoctoral training program. This cross- disciplinary nutrition-focused program provides specialized training to develop a cadre of researchers who can bridge basic, translational, and population science to reduce the growing burden and disparities in GCMD. There is critical need to reduce this burden in low- and middle-income countries that are disproportionately affected and where more specialized skills and global leadership are most needed. The training program is administered in the Department of Nutrition in the Gillings School of Global Public Health and in the UNC School of Medicine, a logical and well-placed home for a GCMD training grant. Nutrition science integrates “omics” (e.g., genomics, proteomics, metabolomics), behavioral, and population approaches and data to understand complex pathobiological processes and underlying causes of population health differences in GCMD, thus providing a strong platform for training translational global researchers in this field. Our program is co-directed by two senior faculty with strong mentoring records and extensive global experience and leadership in GCMD research. The program is guided by an internal training committee and an external advisory board. Our 22 UNC training faculty are scientists with substantial research support, excellent publication records across a wide range of disciplines, and strong mentoring experience. We request support for 5 predoctoral trainees per year. Trainees complete the PhD in nutrition and GCMD program-specific requirements, including specialized courses in global health and cardiovascular disease and options for in-depth training in (1) specialized methods important for GCMD, (2) translational medicine, or (3) implementation science. All trainees participate in a seminar led by the program directors, mentored research practicums, training in the responsible conduct of research, and mentoring for professional development, including submitting an NIH-style predoctoral and/or F award or similar application for extramural funding, and unique global internships with 15 global mentors who are exceptional CMD researchers working at 13 top universities or research centers in 11 countries. Our training program stands out because of its: (1) focus on nutrition, a major etiologic factor in the global disease burden; (2) life course approach to addressing GCMD; (3) interdisciplinary focus on causes ranging from cellular and molecular to whole organism and accounting for underlying social, economic, political, and environmental determinants; (4) emphasis on integration and translation of basic knowledge and discoveries from nutrition biochemistry, physiology, genetics, and epidemiology, to behavioral and environmental approaches and policies; and (5) outstanding faculty mentors who serve as role models for excellence in GCMD research and leaders working with countries to implement and evaluate large-scale regulatory efforts to prevent cardiometabolic disease. The program is training future leaders in GCMD research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $159,884 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	001	10	9/9/2025	NON-COMPETING CONTINUATION	$159,884
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	9	8/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $159,884

Issue Date FY: 2024 ( Subtotal = $189,703 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	9	8/23/2024	NON-COMPETING CONTINUATION	$189,703
														Subtotal = $189,703

Issue Date FY: 2023 ( Subtotal = $239,208 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	8	8/1/2023	NON-COMPETING CONTINUATION	$239,208
														Subtotal = $239,208

Issue Date FY: 2022 ( Subtotal = $166,803 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	004	7	8/1/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	003	7	7/12/2022	NON-COMPETING CONTINUATION	$166,803
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	002	6	12/10/2021	COMPETING CONTINUATION	$167,050
2022	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	001	5	12/10/2021	NON-COMPETING CONTINUATION	-$136,467
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	4	12/10/2021	NON-COMPETING CONTINUATION	-$30,583
														Subtotal = $166,803

Issue Date FY: 2021 ( Subtotal = $107,253 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	001	6	4/29/2021	COMPETING CONTINUATION	$217,754
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	5	11/23/2020	NON-COMPETING CONTINUATION	-$110,501
														Subtotal = $107,253

Issue Date FY: 2020 ( Subtotal = $246,968 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	5	9/22/2020	NON-COMPETING CONTINUATION	$246,968
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	001	5	9/23/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $246,968

Issue Date FY: 2019 ( Subtotal = $244,246 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	4	8/1/2019	NON-COMPETING CONTINUATION	$244,246
														Subtotal = $244,246

Issue Date FY: 2018 ( Subtotal = $241,590 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	3	7/31/2018	NON-COMPETING CONTINUATION	$241,590
														Subtotal = $241,590

Issue Date FY: 2017 ( Subtotal = $238,998 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	2	7/17/2017	NON-COMPETING CONTINUATION	$238,998
														Subtotal = $238,998

Issue Date FY: 2016 ( Subtotal = $236,470 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cardiovascular Diseases Research	000	1	7/29/2016	NEW	$236,470
														Subtotal = $236,470

Grand Total All Awards = $2,071,123

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Global Cardiometabolic Disease Training

Award Number: T32HL129969

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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