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Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders

Award Number: T32HL110952
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/13/2013
PERIOD OF PERFORMANCE END DATE: 06/07/2025

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Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders - ABSTRACT Sleep and circadian disorders have a major impact on public health. Almost all aspects of sleep and circadian rhythm are heritable as are common sleep and circadian disorders. Thus, there is a major opportunity to study the genetic basis of sleep/circadian rhythm and different sleep disorders. Genomic approaches, including development of novel biomarkers, are another area of opportunity. While these major scientific opportunities are available, we do not have the scientific workforce necessary to address them. To address this need, a multi-institutional training grant has been established in genetic/genomics of sleep and circadian disorders. It takes a national, rather than single institutional, perspective. The program is led by faculty at the University of Pennsylvania, which has the most advanced infrastructure for research training. The sites that fellows train at are Johns Hopkins University, University of Michigan and Stanford University. A multidisciplinary, talented faculty has been recruited to provide training. This includes experts in different sleep disorders, in human genetics, in genomic approaches, including RNA seq, and use of multiple model systems such as zebrafish and mice. The latter allows trainees to evaluate the functional role of gene variants identified in human studies. The program has coordinated events that all trainees attend. These include research work- in-progress talks, a grant workshop and lectures on genetics/genomics of sleep and circadian disorders. The program has recruited 8 outstanding MD and PhD postdoctoral trainees, four of whom have already submitted career development grants. All individuals who have entered the program remain in biomedical research in academic settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$537,028 )
2026	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	10	12/17/2025	NON-COMPETING CONTINUATION	-$537,028
														Subtotal = -$537,028

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	10	7/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	10	6/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $260,267 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	10	8/6/2022	NON-COMPETING CONTINUATION	$260,267
														Subtotal = $260,267

Issue Date FY: 2021 ( Subtotal = $732,857 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	9	7/12/2021	NON-COMPETING CONTINUATION	$732,857
														Subtotal = $732,857

Issue Date FY: 2020 ( Subtotal = $488,247 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	8	6/24/2020	NON-COMPETING CONTINUATION	$488,247
														Subtotal = $488,247

Issue Date FY: 2019 ( Subtotal = $499,535 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	003	7	7/3/2019	NON-COMPETING CONTINUATION	$499,535
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	002	6	11/20/2018	COMPETING CONTINUATION	$597,719
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	005	6	9/20/2019	COMPETING CONTINUATION	$28
2019	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	001	5	11/20/2018	NON-COMPETING CONTINUATION	-$321,295
2019	2016	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	4	11/20/2018	EXTENSION WITH OR WITHOUT FUNDS	-$276,424
2019	2016	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	004	4	9/20/2019	EXTENSION WITH OR WITHOUT FUNDS	-$28
														Subtotal = $499,535

Issue Date FY: 2018 ( Subtotal = $667,780 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	001	6	8/6/2018	COMPETING CONTINUATION	$18,593
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	000	6	1/19/2018	COMPETING CONTINUATION	$649,187
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	National Center on Sleep Disorders Research	002	6	9/18/2018	COMPETING CONTINUATION	$0
														Subtotal = $667,780

Issue Date FY: 2017 ( Subtotal = $321,295 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	002	5	6/16/2017	NON-COMPETING CONTINUATION	$321,295
2017	2016	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	001	4	3/2/2017	EXTENSION WITH OR WITHOUT FUNDS	$1,025
2017	2014	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	2	3/2/2017	NON-COMPETING CONTINUATION	-$1,025
														Subtotal = $321,295

Issue Date FY: 2016 ( Subtotal = $663,010 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	4	5/23/2016	EXTENSION WITH OR WITHOUT FUNDS	$663,010
														Subtotal = $663,010

Issue Date FY: 2015 ( Subtotal = $647,009 )
2015	2015	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	3	6/8/2015	NON-COMPETING CONTINUATION	$647,009
														Subtotal = $647,009

Issue Date FY: 2014 ( Subtotal = $509,515 )
2014	2014	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	2	5/5/2014	NON-COMPETING CONTINUATION	$509,515
														Subtotal = $509,515

Issue Date FY: 2013 ( Subtotal = $250,707 )
2013	2013	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	1	7/12/2013	NEW	$250,707
														Subtotal = $250,707

Grand Total All Awards = $4,503,194

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Multi-Institutional Training in Genetic/Genomic Approaches to Sleep Disorders

Award Number: T32HL110952

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/13/2013

PERIOD OF PERFORMANCE END DATE: 06/07/2025

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