Tuesday, May 17, 2022 5/17/2022

Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s National

Award Number: T32HL110841
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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The rationale for this renewal application is to continue our highly collaborative and multidisciplinary, inter- institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology. Our objective is to address the barriers for the conduct of high quality and transformative research in pediatric transfusion medicine and hematology including: 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators. This program is focused on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion, cell therapy and transplantation. The design of the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) is focused on preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program completes a Master's in Clinical and Translational Science (MsCTR) at the George Washington University (GWU) School of Medicine and Health Sciences or equivalent, and will devise, implement and complete a research project under the joint oversight of a multidisciplinary mentorship team. At the completion of the two- to three-year program, each trainee will have presented his/her data to at least one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and for those in a three-year program, submitted an external grant application to the NIH or equivalent funding source. The program is overseen by two NIH-funded Principal Investigators with complementary clinical and research expertise, supported by nine faculty of Children's National and GWU, with four external mentors. All mentors are research scientists with expertise in coagulation, transfusion medicine, cell therapy, transplantation, vascular biology and genomic/proteomics. A Diversity Enhancement Officer will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee of four NIH-funded national leaders in transfusion medicine, transplantation and hematology with established career mentorship programs will offer annual feedback and guidance of the PHTMMRT program and the trainees' progress. The PHTMMRT program will leverage several of Children's National's multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, GWU and Howard University School of Medicine (HUSM). In summary, our multidisciplinary, inter-institutional mentors will train four to five future academic leaders in Pediatric Hematology/Transfusion Medicine including a focus on cell-based therapies for heart, lung and blood diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $120,827 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	10	2/9/2022	NON-COMPETING CONTINUATION	$120,827


Issue Date FY: 2021 ( Subtotal = $205,646 )
2021	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	002	10	10/3/2020	NON-COMPETING CONTINUATION	$48,033
2021	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	10	10/1/2020	NON-COMPETING CONTINUATION	-$48,033
2021	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	001	10	10/3/2020	NON-COMPETING CONTINUATION	-$15,445
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	003	9	2/26/2021	NON-COMPETING CONTINUATION	$221,091


Issue Date FY: 2020 ( Subtotal = $185,306 )
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	8	2/17/2020	NON-COMPETING CONTINUATION	$185,306


Issue Date FY: 2019 ( Subtotal = $286,647 )
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	7	6/5/2019	NON-COMPETING CONTINUATION	$67,885
2019	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	001	6	7/18/2019	COMPETING CONTINUATION	$218,762


Issue Date FY: 2018 ( Subtotal = $81,165 )
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	6	2/1/2018	COMPETING CONTINUATION	$78,815
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	001	6	8/9/2018	COMPETING CONTINUATION	$2,350


Issue Date FY: 2017 ( Subtotal = -$218,762 )
2017	2016	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	002	5	12/13/2016	EXTENSION WITH OR WITHOUT FUNDS	$296,435
2017	2016	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	003	5	6/6/2017	EXTENSION WITH OR WITHOUT FUNDS	-$218,762
2017	2015	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	001	4	12/13/2016	NON-COMPETING CONTINUATION	-$204,524
2017	2014	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	3	12/13/2016	NON-COMPETING CONTINUATION	-$91,911


Issue Date FY: 2016 ( Subtotal = $1 )
2016	2016	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	5	3/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$1


Issue Date FY: 2015 ( Subtotal = $204,524 )
2015	2015	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	4	2/28/2015	NON-COMPETING CONTINUATION	$204,524


Issue Date FY: 2014 ( Subtotal = $296,735 )
2014	2014	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	001	3	3/25/2014	NON-COMPETING CONTINUATION	$4,717
2014	2014	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	3	1/16/2014	NON-COMPETING CONTINUATION	$292,018


Issue Date FY: 2013 ( Subtotal = $219,013 )
2013	2013	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	2	1/24/2013	NON-COMPETING CONTINUATION	$219,013


Issue Date FY: 2012 ( Subtotal = $73,004 )
2012	2012	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	001	1	2/2/2012	NEW	$1,153
2012	2012	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Blood Diseases and Resources Research	000	1	1/11/2012	NEW	$71,851


Grand Total All Awards = $1,454,106

Sum of Action Amount is $1,454,106;

Grand Total = $1,454,106

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Rationale for the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) at Children?s National

Award Number: T32HL110841

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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