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Basic Sciences Studies on Gene Therapy of Blood Diseases

Award Number: T32HL007910
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/1999
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Basic Sciences Studies on Gene Therapy of Blood Diseases - Project Abstract This is a vastly revised competitive renewal of NIH T32 HL-07910 entitled: “Basic Science Studies on Gene Therapy of Blood Diseases” which is in its 20th year of funding. The discipline of gene therapy has made clinical advances, but is still an emerging clinical field that has not come close to yet realizing its potential. To continue to advance the field in quality of vector transduction and engrafting vector-transduced hematopoietic stem, progenitor and other carrier cells, we must train the next generation of dedicated pre-doctoral students and post- doctoral/clinical fellows. Our aim is to continue to train this next generation of scientists in the clinically-relevant medical area of gene transfer for effective modulation of normal and abnormal cell growth and for gene therapy to correct blood diseases. We request 4 pre- and 5 post-doctoral slots as allotted in the last competitive renewal. We have an outstanding group of 25 very productive, interactive, well-respected and NIH funded investigators as mentors with their primary and/or secondary faculty appointments in 10 departments of the medical school. These mentors have over their career trained a total of 241 pre-doctoral PhD and 412 post-doctoral students, and have published more than 3,500 papers (2798 original refereed, and 709 reviews/book chapters), many with their trainees. Since the competitive renewal of this program in 2014, we were able to train and/or were in the process of training 10 pre and 10 post-doctoral students, who have published 72 papers [40 (Pre-Doc) and 32 (Post-Doc)]. The Program Director (PD) has trained 21 pre-doctoral and 57 postdoctoral/clinical fellows, has published 795 papers, cited over 63,000 times with an H-Factor of 120, and been continuously funded by the NIH since 1978. He is a recognized authority on hematopoietic stem/progenitor cells, and regulation of hematopoiesis. The Co-PD, is a well-recognized and well-funded productive investigator in the area of gene transfer/therapy, and hematopoiesis during disease who has trained numerous students and fellows. The PD and Co-PD have had their work translated for clinical benefit and have extensive administrative experience. They have worked for many years in the area of gene transfer to enhance gene therapy. The majority of our trainees, since initial funding of this grant in 1999, have gone on to careers in academia and other research intensive areas of employment. Training of our pre- and post-doctoral students entails one-on-one interactions, committee and group mentorship, lab meetings, a special seminar series, and journal club in the area of this training program, didactic courses, ethical training, presentations at scientific meetings and expectations for them to publish in scientific and medical journals, to present their work at national and international meetings and to become productive independent investigators whose work will benefit healthcare in general and gene transfer/gene therapy in specific. Trainees are rigorously picked for their motivation and past productivity. Training efforts are enhanced by strong internal and external advisory board committees.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $176,297 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	25	7/2/2024	NON-COMPETING CONTINUATION	$176,297
														Subtotal = $176,297

Issue Date FY: 2023 ( Subtotal = $241,320 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	24	5/22/2023	NON-COMPETING CONTINUATION	$241,320
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	23	4/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $241,320

Issue Date FY: 2022 ( Subtotal = $180,798 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	23	6/9/2022	NON-COMPETING CONTINUATION	$180,798
2022	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	22	2/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $180,798

Issue Date FY: 2021 ( Subtotal = $87,201 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	003	22	6/28/2021	NON-COMPETING CONTINUATION	$87,201
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	002	21	2/17/2021	COMPETING CONTINUATION	$507,180
2021	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	20	2/17/2021	NON-COMPETING CONTINUATION	-$193,350
2021	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	19	2/17/2021	NON-COMPETING CONTINUATION	-$313,830
														Subtotal = $87,201

Issue Date FY: 2020 ( Subtotal = $331,293 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	21	6/1/2020	COMPETING CONTINUATION	$331,293
2020	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	20	5/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $331,293

Issue Date FY: 2019 ( Subtotal = $193,350 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	20	12/12/2018	NON-COMPETING CONTINUATION	$193,350
														Subtotal = $193,350

Issue Date FY: 2018 ( Subtotal = $380,561 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	19	12/15/2017	NON-COMPETING CONTINUATION	$367,696
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	19	8/9/2018	NON-COMPETING CONTINUATION	$12,865
														Subtotal = $380,561

Issue Date FY: 2017 ( Subtotal = $434,308 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	002	18	2/14/2017	SUPPLEMENT FOR EXPANSION	$3,498
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	001	18	12/21/2016	NON-COMPETING CONTINUATION	$5,508
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	000	18	11/21/2016	NON-COMPETING CONTINUATION	$423,280
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	004	18	7/7/2017	NON-COMPETING CONTINUATION	$2,022
2017	2012	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Blood Diseases and Resources Research	003	14	5/8/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $434,308

Issue Date FY: 2016 ( Subtotal = $523,280 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	17	11/27/2015	NON-COMPETING CONTINUATION	$510,467
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	001	17	2/26/2016	NON-COMPETING CONTINUATION	$12,813
														Subtotal = $523,280

Issue Date FY: 2015 ( Subtotal = $494,630 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	002	16	2/25/2015	COMPETING CONTINUATION	$6,921
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	003	16	8/17/2015	COMPETING CONTINUATION	$142,713
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	001	16	12/15/2014	COMPETING CONTINUATION	$344,996
2015	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	15	11/29/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $494,630

Issue Date FY: 2013 ( Subtotal = $170,675 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	15	8/15/2013	NON-COMPETING CONTINUATION	$170,675
														Subtotal = $170,675

Issue Date FY: 2012 ( Subtotal = $405,060 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	14	5/31/2012	NON-COMPETING CONTINUATION	$405,060
														Subtotal = $405,060

Issue Date FY: 2011 ( Subtotal = $309,442 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	13	8/12/2011	NON-COMPETING CONTINUATION	$309,442
														Subtotal = $309,442

Issue Date FY: 2010 ( Subtotal = $331,189 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	12	8/18/2010	NON-COMPETING CONTINUATION	$331,189
														Subtotal = $331,189

Issue Date FY: 2009 ( Subtotal = $428,104 )
2009	2009	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	002	11	9/23/2009	COMPETING CONTINUATION	$428,104
2009	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	001	10	9/23/2009	NON-COMPETING CONTINUATION	$0
2009	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	10	7/15/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $428,104

Issue Date FY: 2008 ( Subtotal = $224,032 )
2008	2008	INDIANA UNIVERSITY, BLOOMINGTON	BRYAN 215C	BLOOMINGTON	IN	47405	MONROE	USA	Blood Diseases and Resources Research	000	10	7/1/2008	NON-COMPETING CONTINUATION	$224,032
														Subtotal = $224,032

Issue Date FY: 2007 ( Subtotal = $412,723 ) (Continued on the next page)
Grand Total All Awards = $7,041,596

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Basic Sciences Studies on Gene Therapy of Blood Diseases

Award Number: T32HL007910

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/1999

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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