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Research training in respiratory biology

Award Number: T32HL007605
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/1985
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Research training in respiratory biology - PROJECT SUMMARY The objective of our competing renewal application for the Univ of Chicago Research Training Program in Respiratory Biology is to prepare young scientists to pursue research careers addressing mechanisms and treatment of human disease, with a focus on respiratory pathobiology. The cohesiveness of this interdiscipli- nary Program stems from the highly collaborative nature of our 38 well-funded faculty in 7 departments and the Institute for Molecular Engineering at the Univ of Chicago in multiple areas of concentration. Studies in Asthma and Airway Physiology/Immunology continue to focus on airway inflammation, airway smooth muscle and epithelial structure and function, B-cell and T-cell activation, asthma genetics, and clinical investigation. These complement programs of Studies in Lung Immunology and Transplantation that focus on cellular and molecular mechanisms underlying transplantation immunology and their translational applications to patients, and translational Studies in Interstitial Lung Diseases that draw on one of the largest dedicated clinics in the Midwest. A Concentration in Airway and Mucosal Microbiome adds this critically important emerging research direction to the asthma and ILD programs. Studies in Critical Illness and Acute Lung Injury continue to address subcellular determinants of oxygen sensing and consumption, cellular responses to hypoxia, membrane biology, endothelial and epithelial barrier function, and bedside translations to patients with sepsis, cardiopulmonary arrest, and sleep disturbance. Complementing these are cross-cutting Studies in Genetics and Epigenetics and Concentration in Health Studies and Ethics. The Program Directors are Anne I. Sperling, PhD and Julian Solway, MD, with Associate Director Steven White, MD (Mentorship and Career Development). Christopher Olopade, MD, MPH chairs a Diversity Committee. Internal and External Advisors provide oversight and continuity of review, and an Admissions/Steering Committee reviews trainee progress. We request funding for 10 post-doctoral trainees. PhD, MD, and MD/PhD trainees are enrolled and trained together. Collaboration of basic and clinical scientists on research further enhances the integrative and translational nature of our program. All fellows perform full-time research for at least 2 years, and MD fellows will devote not more than 10% time to clinical training while supported by this Program. Training consists of 5 major components: a Research Project performed under the direct supervision of faculty co-mentors; a Core Curriculum of robust seminar series and courses with additional, tailored formal coursework; Core Competencies that includes scientific communication, grant writing, and mentoring; Multidisciplinary Research; and Individualized Career Development Planning. Prior trainees from this Program have developed successful independent research careers in large proportion. Refinements presented here should further enhance the likelihood for success of future trainees.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2024	THE UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	40	10/8/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $843,574 )
2026	2026	THE UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	001	42	8/20/2026	NON-COMPETING CONTINUATION	$804,574
2026	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	41	2/24/2026	COMPETING CONTINUATION	$39,000
														Subtotal = $843,574

Issue Date FY: 2025 ( Subtotal = $753,456 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	001	41	7/31/2025	COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	41	7/25/2025	COMPETING CONTINUATION	$753,456
														Subtotal = $753,456

Issue Date FY: 2024 ( Subtotal = $950,124 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	40	7/15/2024	NON-COMPETING CONTINUATION	$950,124
														Subtotal = $950,124

Issue Date FY: 2023 ( Subtotal = $889,154 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	008	39	6/23/2023	NON-COMPETING CONTINUATION	$889,154
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	009	39	8/15/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	007	38	6/9/2023	NON-COMPETING CONTINUATION	$0
2023	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	003	36	12/8/2022	COMPETING CONTINUATION	-$539,761
2023	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	001	36	11/9/2022	COMPETING CONTINUATION	-$222,923
2023	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	006	36	12/12/2022	COMPETING CONTINUATION	$762,734
2023	2019	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	005	35	12/12/2022	NON-COMPETING CONTINUATION	-$539,761
2023	2019	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	002	35	12/8/2022	NON-COMPETING CONTINUATION	$539,761
2023	2018	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	34	11/9/2022	NON-COMPETING CONTINUATION	$222,923
2023	2018	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	004	34	12/12/2022	NON-COMPETING CONTINUATION	-$222,973
														Subtotal = $889,154

Issue Date FY: 2022 ( Subtotal = $475,985 )
2022	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	38	9/3/2022	NON-COMPETING CONTINUATION	$475,985
														Subtotal = $475,985

Issue Date FY: 2021 ( Subtotal = $828,000 )
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	004	37	9/13/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	003	37	7/6/2021	NON-COMPETING CONTINUATION	$828,000
2021	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	002	36	2/17/2021	COMPETING CONTINUATION	$762,684
2021	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	001	35	2/17/2021	NON-COMPETING CONTINUATION	-$539,761
2021	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	34	2/17/2021	NON-COMPETING CONTINUATION	-$222,923
														Subtotal = $828,000

Issue Date FY: 2020 ( Subtotal = $815,403 )
2020	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	36	6/25/2020	COMPETING CONTINUATION	$815,403
														Subtotal = $815,403

Issue Date FY: 2019 ( Subtotal = $539,761 )
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	35	7/5/2019	NON-COMPETING CONTINUATION	$539,761
														Subtotal = $539,761

Issue Date FY: 2018 ( Subtotal = $743,863 )
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	34	6/25/2018	NON-COMPETING CONTINUATION	$743,863
														Subtotal = $743,863

Issue Date FY: 2017 ( Subtotal = $739,543 )
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	003	33	5/18/2017	NON-COMPETING CONTINUATION	$727,464
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	32	2/3/2017	SUPPLEMENT FOR EXPANSION	$12,079
2017	2015	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	002	31	3/6/2017	COMPETING CONTINUATION	-$9,144
2017	2013	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	001	29	3/6/2017	NON-COMPETING CONTINUATION	$9,144
														Subtotal = $739,543

Issue Date FY: 2016 ( Subtotal = $705,795 )
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	32	7/11/2016	NON-COMPETING CONTINUATION	$705,795
														Subtotal = $705,795

Issue Date FY: 2015 ( Subtotal = $682,488 )
2015	2015	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	31	2/5/2015	COMPETING CONTINUATION	$682,488
														Subtotal = $682,488

Issue Date FY: 2014 ( Subtotal = $433,348 )
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	30	6/20/2014	NON-COMPETING CONTINUATION	$433,348
														Subtotal = $433,348

Issue Date FY: 2013 ( Subtotal = $653,160 )
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	29	6/21/2013	NON-COMPETING CONTINUATION	$653,160
														Subtotal = $653,160

Issue Date FY: 2012 ( Subtotal = $494,660 )
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Lung Diseases Research	000	28	6/21/2012	NON-COMPETING CONTINUATION	$494,660
														Subtotal = $494,660

Grand Total All Awards = $17,971,972

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Research training in respiratory biology

Award Number: T32HL007605

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/1985

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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