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Training of the Pediatric Physician-Scientist

Award Number: T32HD043010
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2002
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Training of the Pediatric Physician-Scientist - This proposal is the third renewal application for support of the Pediatric Physician-Scientist T32 training program in the Department of Pediatrics (DOP) at Washington University School of Medicine (WUSM). Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician-scientist pipeline at the clinical post-postdoctoral fellowship level, our program supports a mentored career development pathway for 4 Trainees per year (typically for 2 years each) by leveraging a wealth of biomedical research resources across the WUSM campus, the DOP and our Child Health Research Center (NICHD CHRCDA K12). For the past 20 years and going forward, the long-term objective of this program is to develop Trainees who focus their research efforts on pediatric disease-oriented biology by applying recent advances in the basic and translational sciences, such as developmental biology, cell biology, immunology, genetics, multi-omics systems biology, and bioinformatics. The specific aims of this program are to provide selected pediatric subspecialty fellow Trainees with 1) protected mentored research experiences with well-established investigators across a wide range of disciplines related to child health at WashU Medicine and its Department of Pediatrics, 2) NIH-compliant educational programs in laboratory management, scientific rigor, biostatistics, grantsmanship, responsible conduct of research, and biomedical informatics, 3) individualized specific coursework based on each Trainee’s area of investigation (e.g., genomics, computational biology, biostatistics), 4) ongoing constructive feedback to Trainees, mentors, and program leadership, and 5) a flexible environment that facilitates the individualized development of Trainees to achieve their career goals. The program, now 20 years old, has an excellent track record by exceeding national benchmarks (15-year T to K conversion rate = 52%; this cycle = 57%), and will ultimately close the knowledge gap between basic/translational scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D., and David Hunstad, M.D. again serve as the Program Director, and the Training Director, respectively. Our Trainees will continue to utilize a vast array of institutionally funded, state-of-the-art research core facilities that provide, for example, whole-genome/exome DNA sequencing, single-cell RNA sequencing, induced pluripotent stem cells and organoids, bioinformatics, cryo-EM and other advanced imaging, CRISPR-CAS9 genome editing and model animal development, to facilitate the study of pediatric disease states. The long-term goals of this program are being realized as its Trainees contribute to our understanding of development and childhood diseases for decades to come, while evolving into the next generation of scientific leaders, role models, and mentors for subsequent generations of pediatric physician- scientists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $308,056 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	24	4/17/2026	NON-COMPETING CONTINUATION	$308,056
														Subtotal = $308,056

Issue Date FY: 2025 ( Subtotal = $378,330 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	23	6/25/2025	NON-COMPETING CONTINUATION	$378,330
														Subtotal = $378,330

Issue Date FY: 2024 ( Subtotal = $327,854 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	008	22	9/19/2024	NON-COMPETING CONTINUATION	$176,790
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	002	22	5/16/2024	NON-COMPETING CONTINUATION	$151,064
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	007	21	9/18/2024	COMPETING CONTINUATION	$282,198
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	003	21	8/30/2024	COMPETING CONTINUATION	$0
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	001	21	5/1/2024	COMPETING CONTINUATION	$282,198
2024	2023	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	005	21	9/10/2024	COMPETING CONTINUATION	-$282,198
2024	2022	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	006	20	9/18/2024	NON-COMPETING CONTINUATION	-$282,198
2024	2022	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	20	5/1/2024	NON-COMPETING CONTINUATION	-$282,198
2024	2022	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	004	20	9/10/2024	NON-COMPETING CONTINUATION	$282,198
														Subtotal = $327,854

Issue Date FY: 2023 ( Subtotal = $316,270 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	001	21	5/10/2023	COMPETING CONTINUATION	$316,270
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	20	5/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $316,270

Issue Date FY: 2022 ( Subtotal = $300,167 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	20	4/28/2022	NON-COMPETING CONTINUATION	$300,167
														Subtotal = $300,167

Issue Date FY: 2021 ( Subtotal = $317,814 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	19	6/20/2021	NON-COMPETING CONTINUATION	$317,814
														Subtotal = $317,814

Issue Date FY: 2020 ( Subtotal = $308,071 )
2020	2020	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	18	4/23/2020	NON-COMPETING CONTINUATION	$308,071
														Subtotal = $308,071

Issue Date FY: 2019 ( Subtotal = $303,440 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	17	5/6/2019	NON-COMPETING CONTINUATION	$303,440
2019	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	001	16	6/26/2019	COMPETING CONTINUATION	$0
														Subtotal = $303,440

Issue Date FY: 2018 ( Subtotal = $304,843 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	004	16	8/28/2018	COMPETING CONTINUATION	$274,907
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	16	5/4/2018	COMPETING CONTINUATION	$306,795
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	001	16	7/23/2018	COMPETING CONTINUATION	-$1,952
2018	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	003	15	8/28/2018	NON-COMPETING CONTINUATION	-$238,276
2018	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	002	14	8/28/2018	EXTENSION WITH OR WITHOUT FUNDS	-$36,631
														Subtotal = $304,843

Issue Date FY: 2017 ( Subtotal = $238,276 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Child Health and Human Development Extramural Research	000	15	5/17/2017	NON-COMPETING CONTINUATION	$238,276
														Subtotal = $238,276

Issue Date FY: 2016 ( Subtotal = $282,732 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	14	5/6/2016	EXTENSION WITH OR WITHOUT FUNDS	$282,732
														Subtotal = $282,732

Issue Date FY: 2015 ( Subtotal = $238,383 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	13	5/12/2015	NON-COMPETING CONTINUATION	$238,383
														Subtotal = $238,383

Issue Date FY: 2014 ( Subtotal = $250,683 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	12	5/7/2014	NON-COMPETING CONTINUATION	$250,683
														Subtotal = $250,683

Issue Date FY: 2013 ( Subtotal = $264,181 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	001	11	5/6/2013	COMPETING CONTINUATION	$2,040
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	11	4/1/2013	COMPETING CONTINUATION	$262,141
														Subtotal = $264,181

Issue Date FY: 2012 ( Subtotal = $244,334 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	10	4/20/2012	NON-COMPETING CONTINUATION	$244,334
														Subtotal = $244,334

Issue Date FY: 2011 ( Subtotal = $210,335 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	9	5/12/2011	NON-COMPETING CONTINUATION	$210,335
														Subtotal = $210,335

Issue Date FY: 2010 ( Subtotal = $190,956 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Child Health and Human Development Extramural Research	000	8	5/6/2010	NON-COMPETING CONTINUATION	$190,956
														Subtotal = $190,956

Issue Date FY: 2009 ( Subtotal = $253,294 ) (Continued on the next page)
Grand Total All Awards = $6,200,065

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Training of the Pediatric Physician-Scientist

Award Number: T32HD043010

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2002

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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