Tuesday, July 1, 2025 7/1/2025

Research Training in Physiological Adaptations to Stress

Award Number: T32GM154124
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Research Training in Physiological Adaptations to Stress - PROJECT SUMMARY The primary goal of this training program entitled “Research Training in Physiological Adaptations to Stress” (PAS) is to provide a new generation of future scientists with authentic interdisciplinary training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which mediate organismal stress adaptation. Key aspects of the new PAS program include using the One Health interdisciplinary public health framework as a lens for solving human health and disease problems, better integration of entrepreneurial principles to develop a discovery mindset, and applying with fidelity principles of rigor and reproducibility. Familiarity with opportunities and challenges posed by generative artificial intelligence is another key innovation, which we view as a training imperative to prepare our trainees for the 21st century workforce. Value added training in entrepreneurship using a boot camp approach, and team process through the Penn State MBA program will facilitate discovery. Graduate students presently encounter little formal training in regulatory science, and the inter-disciplinary curriculum we propose will better prepare our students for emerging academic and nonacademic biomedical careers. An understanding of the business, legal and regulatory issues which shape key milestones in the biomedical science pathway, and the ability to work in diverse teams will allow our trainees to be leaders of innovation. Here, rigorous research design and core competencies necessary for effective communication are also emphasized. The training program takes advantage of existing faculty biomedical expertise in four academic colleges who have amassed an impressive training record while maintaining research excellence, with an overall time to the PhD of 5 years with little attrition. We propose selection of 5 students per year for a period of two years (total of 24 trainees). Additional institutional matching funds will allow for the training of 7.5 additional trainees. The institutional commitment to our training program is outstanding. A foundational course entitled “Physiological Adaptations to Stress” has been designed specifically for the training program, and will serve as a capstone experience to emphasize program goals using multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation within a rich academic environment with dedicated mentoring, strong research support and institutional commitment is proposed. We envision trainees will continue to participate in program activities at the conclusion of their tenure as a T32 Fellow.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $506,710 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	2	6/5/2025	NON-COMPETING CONTINUATION	$506,710
														Subtotal = $506,710

Issue Date FY: 2024 ( Subtotal = $521,619 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	6/19/2024	NEW	$521,619
														Subtotal = $521,619

Grand Total All Awards = $1,028,329

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Research Training in Physiological Adaptations to Stress

Award Number: T32GM154124

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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