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Training in Systems Pharmacology and Toxicology (T-SPaT)

Award Number: T32GM150536
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2023
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Training in Systems Pharmacology and Toxicology (T-SPaT) - PROJECT SUMMARY/ABSTRACT Over the past few decades, our knowledge of the mechanisms by which cells interact with drugs and toxins has exploded due to new molecular analysis techniques and the application of genomic methods. Accordingly, the emphasis of graduate education in the disciplines of pharmacology and toxicology needs to shift from a reductionist view to a systems approach in which doctoral students are comprehensively trained so they can formulate a strategy to solve important biological questions not only at the molecular, cellular, and tissue levels but also at the whole-animal level. Systems pharmacology and toxicology describes a field of study that considers the broad view of drug action. A systems approach using in vivo animal models is necessary to establish efficacy, safety and the pharmacodynamic/pharmacokinetic profile of candidate drugs but there is a shortage of students trained in this area. This Training in Systems Pharmacology and Toxicology (T-SPaT) Program is designed for PhD students in their second year of graduate study pursuing dissertation research projects in the pharmacological sciences. Trainees (2/year for up to 2 years of support) and 33 Program faculty are drawn from the Graduate Program in Interdisciplinary Biomedical Sciences (GPIBS) and the MD/PhD Program. The T-SPaT program will train students to use an in vivo approach to answering relevant questions in pharmacology and toxicology with emphasis on metabolism, drug design, pharmacodynamics, pharmacokinetics, and signaling. The rationale for the T-SPaT program is that this type of training will provide students with a much broader perspective on pharmacology and toxicology that will better prepare them to conduct safe, ethical and rigorous research as leaders of multidisciplinary research teams in the pharmacological sciences. We will integrate T- SPaT into PhD training programs already active at our graduate training sites in the Little Rock area that include faculty/scientists in the Colleges of Medicine, Pharmacy, and Public Health on the UAMS, the Arkansas Children’s Hospital campus, and at the Food and Drug Administration-funded National Center for Toxicological Research. The unique focus of T-SPaT is training with in vivo systems pharmacological and toxicological approaches and concepts. The objective of T-SPaT is to provide in vivo pharmacology and toxicology training that complement the cellular and molecular training that students receive in their home programs. The training program consists of didactic training in pharmacology, toxicology, physiology, pharmacokinetics, metabolism, biostatistics, grant writing, and the Responsible Conduct of Research along with laboratory research using an in vivo model of human disease. The T-SPaT program will also provide strong mentoring, extensive networking, and teaching and leadership opportunities for its trainees through its programmatic activities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $175,012 )
2025	2025	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	3	5/28/2025	NON-COMPETING CONTINUATION	$175,012
														Subtotal = $175,012

Issue Date FY: 2024 ( Subtotal = $181,576 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	2	5/2/2024	NON-COMPETING CONTINUATION	$181,576
														Subtotal = $181,576

Issue Date FY: 2023 ( Subtotal = $174,046 )
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	6/9/2023	NEW	$174,046
														Subtotal = $174,046

Grand Total All Awards = $530,634

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Training in Systems Pharmacology and Toxicology (T-SPaT)

Award Number: T32GM150536

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2023

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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