Predoctoral Training in Cross-Disciplinary Molecular and Cellular Biology - Project Summary / Abstract The Cross-disciplinary Molecular and Cellular Biology (CMCB) training program at Brandeis University prepares rigorous, quantitative scientists for a range of science-related careers through an innovative, interdisciplinary training approach. Drawing from 5 PhD programs (MCB, Biochemistry & Biophysics, Neuroscience, Physics, and Chemistry) and 31 faculty across 6 departments (Biology, Biochemistry, Chemistry, Physics, Math and Computer Science), CMCB provides comprehensive training through coursework, teaching experience, research presentations, and professional development activities. Core elements include: (1) enhanced quantitative training through required courses (BIOL107 Data Analysis and Statistics Workshop or BIOL131 Introduction to Genomics ) and annual workshops, (2) early career development through Individual Development Plans and Thesis Committee Meetings starting in Year 2, (3) interdisciplinary mentoring through secondary research advisors, and (4) structured professional development including Year 4+ Externships. Since its creation in 2021, CMCB has appointed 24 trainees, all of whom remain in good academic standing and are making strong progress toward their PhDs. The program's effectiveness is evidenced by 10 trainees already publishing papers or preprints, with 3 as first/co-first authors. Externships have enabled trainees to explore careers in scientific publishing, teaching, and biotechnology. Based on trainee, mentor and External Advisory Committee feedback, we are implementing several improvements: (1) expanding the core curriculum and increasing its flexibility through the addition of the recently developed BIOL131 Introduction to Genomics course (noted above) as an optional alternative for the required quantitative analysis course, (2) reducing rotation lengths from 9 weeks to 6 weeks, allowing students to join their thesis labs three months earlier (potentially decreasing time to degree), (3) decreasing required electives from two to one to allow more research time, and (4) appointing an Assistant Program Director focused on helping trainees identify Externship opportunities. Success continues to be measured by: (1) research impact through publications, (2) development of independent scientific thinking, (3) active career development engagement, and (4) successful placement in science careers. The program maintains its commitment to training students with a range of scientific backgrounds and research interests, while continuously adapting to meet evolving training needs in molecular and cellular biology.
