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UNC Integrated Translational Oncology Program (UNC-iTOP)

Award Number: T32CA244125
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/20/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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UNC Integrated Translational Oncology Program (UNC-iTOP) - Abstract The University of North Carolina at Chapel Hill Integrated Translational Oncology Program (UNC-iTOP) is a T32 training program focused on training clinicians (MD/DOs), basic scientists (PhDs), and PhD, MD and MD- PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. We have recruited preceptors/faculty with broad interests who are committed to improving translational oncology and tissue-based research. Led by two physician-scientists with complementary expertise in tissue-based research, clinically applicable preclinical models, and clinical trials, UNC-iTOP has recruited preceptors/faculty who are leaders in their fields. The UNC-iTOP faculty includes members with expertise in translational research focusing on biomarkers of cancer and novel therapies and interventions for patients. All UNC-iTOP faculty have approved IRB protocols and have led prospective clinical protocols and/or trials. Sustained support for UNC-iTOP will enable the continued successful proactive, energetic and sustained efforts to identify, recruit and train promising MD/DO, PhD, and MD-PhD investigators for research careers that will address the knowledge gap in tissue-based translational oncology research. Translational oncology tissue- based research has been critically important for the identification of key drivers of cancer initiation, progression and metastasis. Identifying treatments that target the vulnerabilities at each stage continues to be a broad area of need. Evaluating new therapies in relevant models with more stringent metrics is key to translating findings to the clinic. Validating findings in patients is the overarching goal. To succeed in each area requires a fundamental understanding of the workings of the healthcare and clinical protocol/regulatory system that supports cutting edge research. UNC-iTOP appointed its first trainee class in July 2020, and will continue to provide a unique, dynamic, and comprehensive training program for MD/DO, MD-PhD and PhD trainees committed to translational oncology and tissue-based research. We recognize that translational oncology research involves numerous disciplines and successful advances are the result of interdisciplinary teams. The UNC-iTOP focuses on integrating the “basic”, “clinical”, and “regulatory” teams early on with the overarching goal to develop a cadre of translational scientists (both MD/DO/MD-PhDs and PhDs) who will be the next generation of leaders in the field of oncology research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $369,760 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	8	6/19/2026	NON-COMPETING CONTINUATION	$369,760
														Subtotal = $369,760

Issue Date FY: 2025 ( Subtotal = $440,302 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	7	7/14/2025	NON-COMPETING CONTINUATION	$440,302
2025	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	5	3/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $440,302

Issue Date FY: 2024 ( Subtotal = $567,329 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	003	6	8/6/2024	COMPETING CONTINUATION	$567,329
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	5	1/25/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	002	5	7/29/2024	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	4	2/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $567,329

Issue Date FY: 2023 ( Subtotal = $601,462 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	5	8/23/2023	NON-COMPETING CONTINUATION	$569,539
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	4	8/25/2023	NON-COMPETING CONTINUATION	$31,923
														Subtotal = $601,462

Issue Date FY: 2022 ( Subtotal = $509,212 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	4	8/26/2022	NON-COMPETING CONTINUATION	$509,212
														Subtotal = $509,212

Issue Date FY: 2021 ( Subtotal = $572,494 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	3	9/20/2021	NON-COMPETING CONTINUATION	$24
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	3	8/12/2021	NON-COMPETING CONTINUATION	$572,470
														Subtotal = $572,494

Issue Date FY: 2020 ( Subtotal = $579,408 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	2	8/5/2020	NON-COMPETING CONTINUATION	$579,408
														Subtotal = $579,408

Issue Date FY: 2019 ( Subtotal = $283,433 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	1	9/20/2019	NEW	$283,433
														Subtotal = $283,433

Grand Total All Awards = $3,923,400

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UNC Integrated Translational Oncology Program (UNC-iTOP)

Award Number: T32CA244125

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/20/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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