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Integrative Training in Oncogenic Signaling

Award Number: T32CA193201
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/08/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Integrative Training in Oncogenic Signaling - PROJECT SUMMARY/ABSTRACT This first renewal application seeks continued National Cancer Institute (NCI) support for a successful ‘Integrative Training in Oncogenic Signaling’ (ITOS) Program developed to train postdoctoral fellows by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The programtakes place in an active and growing medical center with state -of-the-art facilities,a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Directorship team with an exceptionally strong cancer research and leadership background, the ITOS Program selects and supports the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee has a primary mentor and one/two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that enhances the overall cancer-relatedresearch training experience. The objectives of the ITOS Programremain unchanged, seeking to provideproactive mentoring, oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and, to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevent, diagnosis, and treat cancer. The ITOS Program has seven essential programmatic components: 1) 33 member Program Faculty who share common cancer research interests and provide essential mentoring for trainees; 2) one to two year experiences in designated Program Faculty laboratories; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries; 4) shared research resource workshops and tailored training in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that equip trainees for independent success; and, 7) opportunities to network nationally at a minimum of two professional conferences each year. In its fourth year, the ITOS Program has graduated 9 fellows; 1MD, 1MD/PhD, 7 PhDs. Trainees from diverse backgrounds, 58% female and 30.8% underrepresented racial/ethnic minorities, whom have all successfully transitioned to positions in academia or industry. Based on the capabilities, capacity, trajectory of MUSC for cancer-related training, and the successful accomplishments achieved during its initial funding period, the ITOS Program is requesting the support for seven postdoctoral trainees each year, representing an increase of two trainee positions. In summary, our ITOS Program offers distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to remain highly attractive to emerging junior investigators locally and nationally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $462,564 )
2025	2025	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	001	10	8/19/2025	NON-COMPETING CONTINUATION	$0
2025	2025	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	10	8/8/2025	NON-COMPETING CONTINUATION	$462,564
														Subtotal = $462,564

Issue Date FY: 2024 ( Subtotal = $469,284 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	9	6/24/2024	NON-COMPETING CONTINUATION	$469,284
														Subtotal = $469,284

Issue Date FY: 2023 ( Subtotal = $326,987 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	8	6/30/2023	NON-COMPETING CONTINUATION	$326,987
														Subtotal = $326,987

Issue Date FY: 2022 ( Subtotal = $360,688 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	003	7	6/21/2022	NON-COMPETING CONTINUATION	$360,688
2022	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	002	6	11/19/2021	COMPETING CONTINUATION	$362,715
2022	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	001	5	11/19/2021	NON-COMPETING CONTINUATION	-$361,325
2022	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	4	11/19/2021	NON-COMPETING CONTINUATION	-$1,390
														Subtotal = $360,688

Issue Date FY: 2021 ( Subtotal = $420,612 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	002	6	7/20/2021	COMPETING CONTINUATION	$420,612
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	001	5	7/12/2021	NON-COMPETING CONTINUATION	$0
2021	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	5	4/19/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $420,612

Issue Date FY: 2020 ( Subtotal = $361,325 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	5	6/29/2020	NON-COMPETING CONTINUATION	$361,325
														Subtotal = $361,325

Issue Date FY: 2019 ( Subtotal = $313,713 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	4	6/25/2019	NON-COMPETING CONTINUATION	$313,713
														Subtotal = $313,713

Issue Date FY: 2018 ( Subtotal = $313,312 )
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	3	6/15/2018	NON-COMPETING CONTINUATION	$313,312
														Subtotal = $313,312

Issue Date FY: 2017 ( Subtotal = $318,021 )
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	001	2	7/10/2017	NON-COMPETING CONTINUATION	$3,000
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Research Manpower	000	2	6/27/2017	NON-COMPETING CONTINUATION	$315,021
														Subtotal = $318,021

Issue Date FY: 2016 ( Subtotal = $303,933 )
2016	2016	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Research Manpower	000	1	7/7/2016	NEW	$303,933
														Subtotal = $303,933

Grand Total All Awards = $3,650,439

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Integrative Training in Oncogenic Signaling

Award Number: T32CA193201

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/08/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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