Thursday, July 3, 2025 7/3/2025

DNA Damage Response and Oncogenic Signaling

Award Number: T32CA186895
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/14/2016
PERIOD OF PERFORMANCE END DATE: 02/28/2027

Group Awards By:

View Award Description

DNA Damage Response and Oncogenic Signaling - Project Summary Increases in cancer incidence and rising cancer costs highlight the need to advance cancer biology through the growth of a well-trained workforce. Almost all human cancers have alterations in signaling pathways associated with DNA damage response and oncogenic signaling, and such pathways are also the focus of targeted therapies already in the clinic and under development. To train the next generation of cancer researchers, we have developed an institution-wide cancer biology training program for postdoctoral fellows focused on this area of cancer research, called the DNADRS program. This program is housed at the City of Hope, an NCI-designated Comprehensive Cancer Center, which is known internationally for clinical cancer research and has an outstanding record of basic cancer research. This T32 program began in 2016, and this is the first renewal application. The 3 T32-supported postdoctoral trainees supported for up to 3 years are selected for the DNADRS program through a rigorous process, including a personal interview. Each trainee establishes a mentoring committee that includes a physician to foster cross-pollination of ideas between the basic and translational aspects of cancer research. Annual reappointment is based on annual written reports from the trainee and mentoring committee. As part of a recruitment incentive in the DNADRS program, City of Hope will continue to provide an additional postdoctoral trainee position for every underrepresented minority trainee recruited, up to a total of 6 positions. Furthermore, to attract the best postdoctoral candidates at a national level, City of Hope continues to commit to salary supplementation for all DNADRS trainees, a stipend for research supplies, and full administrative and faculty salary support. Trainees will be mentored by 18 faculty members, all of whom are performing cancer-focused high-impact research and have a history of mentoring postdoctoral fellows. To enhance their chances of developing into independent cancer researchers, all DNADRS trainees take a unique common curriculum that provides a continuum of learning including scientific coursework that includes ethical conduct of research and proper research design, as well as professional development courses. In addition, trainees participate in cutting-edge research programs, journal clubs, seminars, symposiums, regular luncheons with mentors, mentoring committee meetings, national and international scientific conferences, and finally a yearly DNADRS Symposium. The stellar and comprehensive Shared Resource Facilities associated with the Cancer Center provide training in state-of the art technologies. The request for funding to renew this research training grant is justified by our track-record from the last funding cycle of seven successful trainees that include three underrepresented minority fellows, the relevance of the research training to cancer, the experience of the mentors, the outstanding commitment of City of Hope, and the diverse population of the geographical area served by our institution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $249,533 )
2025	2025	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	9	3/28/2025	NON-COMPETING CONTINUATION	$245,477
2025	2025	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	001	9	5/22/2025	NON-COMPETING CONTINUATION	$4,056
														Subtotal = $249,533

Issue Date FY: 2024 ( Subtotal = $240,284 )
2024	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	001	8	3/15/2024	NON-COMPETING CONTINUATION	$223,322
2024	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	002	8	5/7/2024	NON-COMPETING CONTINUATION	$16,962
2024	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	7	12/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $240,284

Issue Date FY: 2023 ( Subtotal = $234,585 )
2023	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	7	3/31/2023	NON-COMPETING CONTINUATION	$234,585
														Subtotal = $234,585

Issue Date FY: 2022 ( Subtotal = $233,749 )
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	001	6	2/21/2022	COMPETING CONTINUATION	$200,853
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	002	6	6/23/2022	COMPETING CONTINUATION	$3,940
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	004	6	7/7/2022	COMPETING CONTINUATION	$1
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	005	6	8/17/2022	COMPETING CONTINUATION	$28,956
2022	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	5	2/11/2022	NON-COMPETING CONTINUATION	$0
2022	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	003	5	7/7/2022	NON-COMPETING CONTINUATION	-$1
														Subtotal = $233,749

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	5	6/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $200,670 )
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	5	6/22/2020	NON-COMPETING CONTINUATION	$200,670
														Subtotal = $200,670

Issue Date FY: 2019 ( Subtotal = $123,474 )
2019	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	4	6/17/2019	NON-COMPETING CONTINUATION	$123,474
														Subtotal = $123,474

Issue Date FY: 2018 ( Subtotal = $181,497 )
2018	2018	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	3	7/13/2018	NON-COMPETING CONTINUATION	$181,497
														Subtotal = $181,497

Issue Date FY: 2017 ( Subtotal = $191,581 )
2017	2017	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	2	6/30/2017	NON-COMPETING CONTINUATION	$191,581
														Subtotal = $191,581

Issue Date FY: 2016 ( Subtotal = $185,062 )
2016	2016	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	1	7/14/2016	NEW	$185,062
														Subtotal = $185,062

Grand Total All Awards = $1,840,435

Top

All Categories

About

Search

Reports

Data Submission

Award Information

DNA Damage Response and Oncogenic Signaling

Award Number: T32CA186895

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/14/2016

PERIOD OF PERFORMANCE END DATE: 02/28/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer