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Cancer Cell Biology Training Program

Award Number: T32CA071341
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/30/1996
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Cancer Cell Biology Training Program - Abstract This application seeks the continuation of the University of North Carolina at Chapel Hill (UNC)'s longstanding and highly successful Cancer Cell Biology Training Program (CCBTP), the flagship and sole predoctoral-only cancer-focused T32 of UNC's Lineberger Comprehensive Cancer Center. CCBTP is now in its 25th year. As we always have more highly qualified applicants than we can accommodate, we request renewed support for all six predoctoral training slots. The premise of CCTBP is that the biology of cancer cells is an interdisciplinary biomedical science encompassing experimental approaches and didactic knowledge from diverse fields. The CCBTP mission is to train the next generation of basic and translational cancer biologists, preparing them to contribute in both academic and non-academic careers. As a non degree-granting program, CCBTP provides trainees with unique opportunities beyond their departmental requirements and offerings. In this renewal application, CCBTP seeks to build on past success, while also recognizing that the landscape of cancer research and training has entered a new era of very dynamic change. Precision medicine and the genomic era of big data in cancer research continue to evolve at warp speed. Dramatic improvements in technology have enabled increased understanding of the contributions of single cells to specific populations, and to the interactions of cancer cells with their tumor microenvironment of stromal and immune cells. To keep the CCBTP program fresh and to best address the needs of future cancer biology trainees, we have critically evaluated the program and remodeled some aspects to keep abreast of this changing landscape. Our refreshed program thus includes a revised core course on cancer pathobiology and signaling, a new core course developed specifically for CCBTP on cancer immunology and the tumor microenvironment, and our unique experiential course on targeted cancer therapeutics. In the past cycle, CCBTP added novel interactions with faculty mentors, improved the diversity pipeline, and obtained enhanced institutional support. We continue to build on all of these improvements. Going forward, in addition to continued emphasis on both basic and translational cancer biology, trainees have new opportunities to develop and utilize their knowledge of state-of-the-art methodologies to profile and dissect the cancer genome, kinome and proteome; to become familiar with bioinformatics and computational biology; to engage with the rapidly emerging areas of immunotherapy and the tumor microenvironment; to understand and apply the most appropriate and useful model systems to study cancer biology; to enhance the rigor and reproducibility of their research; and to engage thoughtfully with the larger world outside their own labs and institution. CCBTP trainees describe their community as one of the most important and valuable aspects of their predoctoral training. The CCBTP serves a vital role in our mission of training to support the pipeline of future cancer biologists, preparing them to accelerate progress in the understanding and treatment of cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	28	12/2/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $251,339 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	28	7/25/2025	NON-COMPETING CONTINUATION	$251,339
														Subtotal = $251,339

Issue Date FY: 2024 ( Subtotal = $332,856 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	002	27	7/23/2024	NON-COMPETING CONTINUATION	$332,856
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	26	6/24/2024	COMPETING CONTINUATION	$6,841
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	25	6/24/2024	NON-COMPETING CONTINUATION	-$6,841
														Subtotal = $332,856

Issue Date FY: 2023 ( Subtotal = $314,720 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	26	6/23/2023	COMPETING CONTINUATION	$314,720
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	25	6/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $314,720

Issue Date FY: 2021 ( Subtotal = $235,562 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	25	8/13/2021	NON-COMPETING CONTINUATION	$235,562
														Subtotal = $235,562

Issue Date FY: 2020 ( Subtotal = $147,058 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	24	8/14/2020	NON-COMPETING CONTINUATION	$147,058
														Subtotal = $147,058

Issue Date FY: 2019 ( Subtotal = $234,992 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	23	8/5/2019	NON-COMPETING CONTINUATION	$234,992
														Subtotal = $234,992

Issue Date FY: 2018 ( Subtotal = $147,378 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	002	22	9/5/2018	NON-COMPETING CONTINUATION	$147,378
2018	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	21	2/22/2018	COMPETING CONTINUATION	$241,911
2018	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	20	2/22/2018	EXTENSION WITH OR WITHOUT FUNDS	-$241,911
														Subtotal = $147,378

Issue Date FY: 2017 ( Subtotal = $167,026 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	003	21	7/5/2017	COMPETING CONTINUATION	$167,026
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	002	20	3/15/2017	EXTENSION WITH OR WITHOUT FUNDS	$274,106
2017	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	19	3/15/2017	NON-COMPETING CONTINUATION	-$270,447
2017	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	18	3/15/2017	NON-COMPETING CONTINUATION	-$3,659
														Subtotal = $167,026

Issue Date FY: 2016 ( Subtotal = $205,844 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	20	8/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$205,844
														Subtotal = $205,844

Issue Date FY: 2015 ( Subtotal = $270,447 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	19	7/28/2015	NON-COMPETING CONTINUATION	$270,447
														Subtotal = $270,447

Issue Date FY: 2014 ( Subtotal = $196,202 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	18	8/8/2014	NON-COMPETING CONTINUATION	$196,202
														Subtotal = $196,202

Issue Date FY: 2013 ( Subtotal = $238,995 )
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	17	9/13/2013	NON-COMPETING CONTINUATION	$238,995
														Subtotal = $238,995

Issue Date FY: 2012 ( Subtotal = $204,581 )
2012	2012	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	001	16	9/25/2012	COMPETING CONTINUATION	$204,581
2012	2010	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	15	9/19/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $204,581

Issue Date FY: 2010 ( Subtotal = $188,294 )
2010	2010	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	15	8/11/2010	NON-COMPETING CONTINUATION	$188,294
														Subtotal = $188,294

Issue Date FY: 2009 ( Subtotal = $194,752 )
2009	2009	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	14	6/3/2009	NON-COMPETING CONTINUATION	$194,752
														Subtotal = $194,752

Issue Date FY: 2008 ( Subtotal = $196,303 )
2008	2008	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	13	7/11/2008	NON-COMPETING CONTINUATION	$196,303
														Subtotal = $196,303

Issue Date FY: 2007 ( Subtotal = $211,676 )
2007	2007	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	12	9/7/2007	NON-COMPETING CONTINUATION	$211,676
														Subtotal = $211,676

Issue Date FY: 2006 ( Subtotal = $143,282 )
2006	2006	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	11	8/31/2006	COMPETING CONTINUATION	$143,282
														Subtotal = $143,282

Issue Date FY: 2004 ( Subtotal = $162,676 )
2004	2004	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Research Manpower	000	9	9/13/2004	NON-COMPETING CONTINUATION	$162,676
														Subtotal = $162,676

Issue Date FY: 2003 ( Subtotal = $169,736 ) (Continued on the next page)
Grand Total All Awards = $4,851,024

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Cancer Cell Biology Training Program

Award Number: T32CA071341

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/30/1996

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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