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Training in Basic Research on Aging and Age-Related Disease

Award Number: T32AG000266
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/1998
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Training in Basic Research on Aging and Age-Related Disease - PROJECT SUMMARY Age is the largest single risk factor for the majority of diseases seen in clinics throughout the U.S. Demo-graphic calculations predict that eliminating any single age-related disease would produce only a modest in-crease in human health span (years of healthy life) or life span. However, postponing or decreasing the rate of aging would retard the course of multiple age-related diseases and thus substantially increase health span and likely life span. Our ability to develop rational approaches to preventing or intervening in the debilitating and costly consequences of aging depends crucially on a thorough understanding of the causes of aging and how they interact with the etiology of specific age-related diseases. Training young scientists to integrate research on basic aging mechanisms with mechanisms of specific age-related diseases is a critical objective of this application. The long-term goal of this training program is to provide exceptional young scientists with the broad knowledge, skills and interactions they will need to mitigate, through research, the enormous human and financial burdens caused by aging and age-related diseases. This program will train postdoctoral fellows to become future leaders in aging research. Each year, the program will train 10 talented postdoctoral scientists who will conduct research for a 2-year period in one or more of 38 laboratories headed by outstanding preceptors at the Buck Institute for Research on Aging, University of California, Berkeley and Stanford University. Trainees will participate in research projects that include basic mechanisms of cellular stress responses, protein homeostasis, genomic and epigenomic stability, stem cell maintenance, bio-energetics and energy metabolism and hormonal, growth factor and nutrient signaling pathways. They will utilize a variety of model systems including yeast, round and flat worms, fruit flies, fish, mice and human cells and tissues. And they will focus on an array of age-related diseases including Alzheimer’s, Parkinson’s and Huntington’s diseases, stroke, cardiac and vascular dysfunction, cancer, diabetes, osteoporosis and sarcopenia. Trainees will be instructed in state-of-the-art techniques in genomics, epigenomics, drug screening, proteomics and metabolomics, as well as genetics, biochemistry, structural biology, cell biology, and cell and organismal imaging. They will receive the benefits of diverse seminar series and other scientific events and frequent net- working opportunities. They will also attend courses in specialized scientific topics, as well as courses or discussion groups on geriatric medicine, ethics, presentation skills, proposal and manuscript writing, and laboratory management skills. The program will fill an important national and international need for high-quality advanced training that integrates basic aging research with research on age-related disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	26	4/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $842,182 )
2024	2024	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	004	26	5/31/2024	NON-COMPETING CONTINUATION	$842,182
2024	2023	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	003	25	2/21/2024	COMPETING CONTINUATION	$0
2024	2023	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	002	25	2/1/2024	COMPETING CONTINUATION	$0
2024	2023	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	25	12/1/2023	COMPETING CONTINUATION	$639,746
2024	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	24	12/1/2023	NON-COMPETING CONTINUATION	-$639,746
														Subtotal = $842,182

Issue Date FY: 2023 ( Subtotal = $785,981 )
2023	2023	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	25	5/1/2023	COMPETING CONTINUATION	$785,981
2023	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	24	11/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $785,981

Issue Date FY: 2022 ( Subtotal = $653,397 )
2022	2022	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	24	6/28/2022	NON-COMPETING CONTINUATION	$653,397
2022	2021	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	23	11/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $653,397

Issue Date FY: 2021 ( Subtotal = $726,862 )
2021	2021	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	23	5/19/2021	NON-COMPETING CONTINUATION	$726,862
2021	2020	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	22	10/20/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $726,862

Issue Date FY: 2020 ( Subtotal = $715,392 )
2020	2020	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	002	22	6/12/2020	NON-COMPETING CONTINUATION	-$4,082
2020	2020	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	22	5/26/2020	NON-COMPETING CONTINUATION	$719,474
2020	2019	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	21	11/28/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $715,392

Issue Date FY: 2019 ( Subtotal = $675,432 )
2019	2019	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	21	5/13/2019	NON-COMPETING CONTINUATION	$675,432
2019	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	20	11/27/2018	COMPETING CONTINUATION	$0
														Subtotal = $675,432

Issue Date FY: 2018 ( Subtotal = $647,654 )
2018	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	003	20	5/22/2018	COMPETING CONTINUATION	$647,654
2018	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	004	20	9/18/2018	COMPETING CONTINUATION	$235,818
2018	2017	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	005	19	9/18/2018	SUPPLEMENT FOR EXPANSION	-$235,818
2018	2017	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	002	19	5/18/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	19	2/1/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
2018	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	19	5/18/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $647,654

Issue Date FY: 2017 ( Subtotal = $373,503 )
2017	2017	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	005	19	9/22/2017	SUPPLEMENT FOR EXPANSION	$251,800
2017	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	19	11/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$467,742
2017	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	003	19	8/4/2017	EXTENSION WITH OR WITHOUT FUNDS	-$126,500
2017	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	004	19	8/18/2017	EXTENSION WITH OR WITHOUT FUNDS	$121,703
2017	2015	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	18	11/29/2016	NON-COMPETING CONTINUATION	-$467,742
2017	2015	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	002	18	8/4/2017	NON-COMPETING CONTINUATION	$126,500
														Subtotal = $373,503

Issue Date FY: 2016 ( Subtotal = $428,123 )
2016	2016	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BOULEVARD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	19	4/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$428,123
														Subtotal = $428,123

Issue Date FY: 2015 ( Subtotal = $584,414 )
2015	2015	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BOULEVARD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	18	4/29/2015	NON-COMPETING CONTINUATION	$584,414
														Subtotal = $584,414

Issue Date FY: 2014 ( Subtotal = $581,329 )
2014	2014	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BOULEVARD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	17	4/28/2014	NON-COMPETING CONTINUATION	$581,329
														Subtotal = $581,329

Issue Date FY: 2013 ( Subtotal = $558,999 )
2013	2013	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	16	5/7/2013	NON-COMPETING CONTINUATION	$503,100
2013	2013	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	16	5/20/2013	NON-COMPETING CONTINUATION	$55,899
														Subtotal = $558,999

Issue Date FY: 2012 ( Subtotal = $545,067 )
2012	2012	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	15	4/30/2012	COMPETING CONTINUATION	$545,067
														Subtotal = $545,067

Issue Date FY: 2011 ( Subtotal = $262,424 ) (Continued on the next page)
Grand Total All Awards = $12,347,328

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Training in Basic Research on Aging and Age-Related Disease

Award Number: T32AG000266

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/1998

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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