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Regulation of the Sinorhizobium meliloti ExoS/ChvI signaling pathway critical for host infection

Award Number: SC3GM144065
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Regulation of the Sinorhizobium meliloti ExoS/ChvI signaling pathway critical for host infection - PROJECT SUMMARY/ABSTRACT Many alpha-proteobacteria invade cells of eukaryotic hosts with pathogenic or beneficial outcomes. Examples of such alpha-proteobacteria are the human pathogens Brucella and Bartonella and the plant symbiont Sinorhizobium. Remarkably, although these alpha-proteobacteria target different cell types in different hosts, they all require a conserved bacterial two-component signaling pathway for successful host interaction: BvrS/BvrR in Brucella, BatS/BatR in Bartonella, and ExoS/ChvI in Sinorhizobium. Mutant bacteria deficient in this pathway fail to invade host cells and exhibit pleiotropic phenotypes such as altered cell envelope function. However, the molecular mechanisms underlying these defects are not well understood. Toward elucidating the crucial roles of this conserved signaling pathway, this project focuses on the ExoS/ChvI signaling pathway of Sinorhizobium meliloti, a model alpha-proteobacterium for studying interactions with eukaryotic hosts. A recent genome-wide study identified 64 protein-encoding genes in the ExoS/ChvI regulon of S. meliloti. This proposal builds from that study and uses molecular genetic approaches to clarify the critical functions of this conserved regulatory pathway. Specific aims of the project are to: (1) Identify small RNA genes directly regulated by ExoS/ChvI, (2) Identify regulatory inputs to ExoS/ChvI, and (3) Characterize transcriptional target genes of ExoS/ChvI. This study will provide insight into the functions controlled by this important signaling pathway during host interaction. In addition, the project will provide valuable biomedical research training to undergraduate and master’s students, including those from groups underrepresented in biomedical research careers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CSU FULLERTON AUXILIARY SERVICES CORPORATION	1121 N STATE COLLEGE BLVD	FULLERTON	CA	92831	ORANGE	USA	Biomedical Research and Research Training	000	4	8/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $106,500 )
2024	2024	CSU FULLERTON AUXILIARY SERVICES CORPORATION	1121 N STATE COLLEGE BLVD	FULLERTON	CA	92831	ORANGE	USA	Biomedical Research and Research Training	000	4	8/20/2024	NON-COMPETING CONTINUATION	$106,500
														Subtotal = $106,500

Issue Date FY: 2023 ( Subtotal = $106,500 )
2023	2023	CSU FULLERTON AUXILIARY SERVICES CORPORATION	1121 N STATE COLLEGE BLVD	FULLERTON	CA	92831	ORANGE	USA	Biomedical Research and Research Training	000	3	8/16/2023	NON-COMPETING CONTINUATION	$106,500
														Subtotal = $106,500

Issue Date FY: 2022 ( Subtotal = $106,500 )
2022	2022	CSU FULLERTON AUXILIARY SERVICES CORPORATION	1121 NORTH STATE COLLEGE BOULEVARD	FULLERTON	CA	92831	ORANGE	USA	Biomedical Research and Research Training	000	2	8/10/2022	NON-COMPETING CONTINUATION	$106,500
														Subtotal = $106,500

Issue Date FY: 2021 ( Subtotal = $106,500 )
2021	2021	CSU FULLERTON AUXILIARY SERVICES CORPORATION	1121 NORTH STATE COLLEGE BOULEVARD	FULLERTON	CA	92831	ORANGE	USA	Biomedical Research and Research Training	000	1	9/20/2021	NEW	$106,500
														Subtotal = $106,500

Grand Total All Awards = $426,000

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Regulation of the Sinorhizobium meliloti ExoS/ChvI signaling pathway critical for host infection

Award Number: SC3GM144065

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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