Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating

Award Number: SC3GM136590
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

Group Awards By:

View Award Description

Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating - Project Summary/Abstract The primary objective of the proposed project is to prepare surface supportive porous inorganic framework thin films that have superior properties for drug delivery. The second objective, which helps with the realization of the first one, is to identify and better understand the chemical and structural features that have the greatest impact on the drug loading and releasing conditions. To accomplish these objectives, the PI proposes to modify and identify suitable surface platforms (with specific chemical features) that can be used to attach selective iron-containing metal organic framework (Fe-MOF) thin films. These biodegradable Fe-MOFs are composed of Fe(III) clusters and various organic ligands as struts forming three-dimensional porous structures. The organic nodes can also serve as binding sites to crosslink with functionalized metal substrates. The drug loading/releasing with surface-supportive Fe-MOF thin films will be examined by spectroscopic and microscopic methods. We will also evaluate the toxicity and mechanical durability of these Fe- MOF coatings. The performance of these iron-containing inorganic frameworks as drug carriers will be studied in vitro using surface techniques. The knowledge acquired from these initial studies will be beneficial for the future in vivo studies of applying these Fe-MOF thin films as potential drug-eluting stent coatings. In addition, the project aims to enhance the scientific understanding of surface and interface interactions between porous hybrid materials and assorted therapeutic agents. These results will lead to new insights and guide the material design for future drug- eluting stents. The proposed research activities will provide excellent health-related research- education opportunities for students in a minority serving institution like ours, which will bring a significant positive impact to our community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	CALIFORNIA STATE UNIVERSITY LONG BEACH RESEARCH FOUNDATION	6300 E STATE UNIVERSITY DR STE 332	LONG BEACH	CA	90815	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	3/31/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $110,625 )
2023	2023	CALIFORNIA STATE UNIVERSITY, LONG BEACH RESEARCH FOUNDATION	6300 E STATE UNIVERSITY DR STE 332	LONG BEACH	CA	90815	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	8/28/2023	NON-COMPETING CONTINUATION	$110,625
														Subtotal = $110,625

Issue Date FY: 2022 ( Subtotal = $110,625 )
2022	2022	CALIFORNIA STATE UNIVERSITY, LONG BEACH RESEARCH FOUNDATION	6300 E STATE UNIVERSITY DR STE 332	LONG BEACH	CA	90815	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	9/9/2022	NON-COMPETING CONTINUATION	$110,625
														Subtotal = $110,625

Issue Date FY: 2021 ( Subtotal = $110,625 )
2021	2021	CALIFORNIA STATE UNIVERSITY, LONG BEACH RESEARCH FOUNDATION	6300 E STATE UNIVERSITY DR STE 332	LONG BEACH	CA	90815	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	8/10/2021	NON-COMPETING CONTINUATION	$110,625
														Subtotal = $110,625

Issue Date FY: 2020 ( Subtotal = $110,625 )
2020	2020	CALIFORNIA STATE UNIVERSITY, LONG BEACH RESEARCH FOUNDATION	6300 E STATE UNIVERSITY DR STE 332	LONG BEACH	CA	90815	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	9/11/2020	NEW	$110,625
														Subtotal = $110,625

Grand Total All Awards = $442,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating

Award Number: SC3GM136590

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer