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The Impact of Patterned Feeding of a Palatable Diet on Excessive Alcohol Drinking

Award Number: SC3GM127173
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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The Impact of Patterned Feeding of a Palatable Diet on Excessive Alcohol Drinking - Summary: Alcohol use disorder (AUD) presents a significant social and economic burden to modern society. Notably, impaired physiological and metabolic status observed in alcoholic patients adversely affects treatment outcome. Furthermore, many alcoholics are malnourished and resultant nutritional deficiencies may contribute to the pathology of alcoholism. However, nutrition is often overlooked as an important treatment component for AUD. Our preliminary data indicate that a patterned feeding (produced by an intermittent availability) of a nutritionally complete palatable diet (NPD), a treatment that does not influence body weight or composition, induces anxiolytic behavior and attenuates alcohol intake in non-dependent rodents, which has important clinical implications in the management of AUD. However, a critical first step involves determining if such dietary intervention would be successful in regulating alcohol intake in preclinical models of AUD. Addressing these critical questions is important to understand the role of compromised nutritional status in regulating various symptoms associated with this multifaceted disorder. P-line of rats has been shown to display proposed criteria (e.g., voluntary excessive and relapse-like alcohol drinking and the emergence of alcohol dependence following chronic alcohol exposure) to be considered as a suitable animal model for studying AUD. The objective of this application is to evaluate excessive and relapse-like alcohol consumption in the alcohol-preferring (P) and non-preferring (NP) rats following patterned feeding of NPD. In addition, we will also determine the underlying behavioral and neurobiological mechanisms mediating the effects of our feeding paradigm. Aim 1 will examine the impact of patterned feeding of NPD on non-dependent excessive and relapse-like alcohol drinking behavior. Aim 2 will evaluate the effect of a similar dietary approach on alcohol dependence-induced negative emotional states, escalated alcohol intake and neurobiological changes in the cortico-striatal circuitry. Aim 3 will examine the role of medial prefrontal cortex (mPFC) neurotensin signaling in regulating effects of NPD on alcohol drinking. The central prediction is that patterned feeding of NPD attenuates problematic alcohol consumption and negative emotional states in rodent’s models of AUD by recruiting mPFC neurotensin signaling. This hypothesis is supported by our preliminary data and work of others. Treating metabolic deficiencies present in the alcoholic condition is a significant conceptual innovation as none of the currently approved approaches target both altered nutritional and emotional states associated with AUD. In addition to restoring nutritional deficits, exposure to NPD could also serve to restore emotional state thereby enhancing other behavioral and pharmacological strategies for the management of alcoholism which will facilitate the pathway to abstinence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$499 )
2025	2022	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	4	4/16/2025	NON-COMPETING CONTINUATION	-$499
														Subtotal = -$499

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	001	4	8/20/2024	NON-COMPETING CONTINUATION	$0
2024	2022	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	4	2/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $106,500 )
2022	2022	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	001	4	6/27/2022	NON-COMPETING CONTINUATION	$10,650
2022	2022	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	4	1/5/2022	NON-COMPETING CONTINUATION	$95,850
														Subtotal = $106,500

Issue Date FY: 2021 ( Subtotal = $106,500 )
2021	2021	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	3	1/28/2021	NON-COMPETING CONTINUATION	$95,850
2021	2021	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	001	3	2/19/2021	NON-COMPETING CONTINUATION	$10,650
														Subtotal = $106,500

Issue Date FY: 2020 ( Subtotal = $106,500 )
2020	2020	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	2	1/23/2020	NON-COMPETING CONTINUATION	$95,850
2020	2020	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	001	2	3/24/2020	NON-COMPETING CONTINUATION	$10,650
														Subtotal = $106,500

Issue Date FY: 2019 ( Subtotal = $106,500 )
2019	2019	XAVIER UNIVERSITY OF LOUISIANA	1 DREXEL DR	NEW ORLEANS	LA	70125	ORLEANS	USA	Biomedical Research and Research Training	000	1	1/31/2019	NEW	$106,500
														Subtotal = $106,500

Grand Total All Awards = $425,501

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The Impact of Patterned Feeding of a Palatable Diet on Excessive Alcohol Drinking

Award Number: SC3GM127173

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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