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Investigating dopaminergic neuronal circuits mediating circadian entrainment to scheduled feeding

Award Number: SC3GM125570
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/13/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2023

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Investigating dopaminergic neuronal circuits mediating circadian entrainment to scheduled feeding - Project Summary This project follows up on our recent research implicating the neurotransmitter dopamine signaling as key mediator of circadian timing systems. Our main hypothesis is a subpopulation of dopaminergic neurons send signals to a population of dopamine type 1 receptor 1 (D1r)-expressing neurons in the dorsal striatum, constituting a critical link between food intake and circadian rhythms of daily activity. To address this hypothesis we propose to generate several genetically modified mice and test their behavioral and physiological entrainment to scheduled feeding. These results will expand our understanding of how the downstream targets of dopamine neurons control several important aspects of feeding related behaviors. In addition, since there are numerous dopaminergic drugs available, this research may suggest potential therapeutic strategies to target diseases associated with over- and under-eating.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$132 )
2024	2021	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	2/14/2024	NON-COMPETING CONTINUATION	-$132
														Subtotal = -$132

Issue Date FY: 2021 ( Subtotal = $110,250 )
2021	2021	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	001	4	2/17/2021	NON-COMPETING CONTINUATION	$11,025
2021	2021	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	1/28/2021	NON-COMPETING CONTINUATION	$99,225
														Subtotal = $110,250

Issue Date FY: 2020 ( Subtotal = $110,250 )
2020	2020	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	1/31/2020	NON-COMPETING CONTINUATION	$99,225
2020	2020	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	3/16/2020	NON-COMPETING CONTINUATION	$11,025
														Subtotal = $110,250

Issue Date FY: 2019 ( Subtotal = $110,250 )
2019	2019	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	1/3/2019	NON-COMPETING CONTINUATION	$110,250
														Subtotal = $110,250

Issue Date FY: 2018 ( Subtotal = $109,938 )
2018	2018	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	2/13/2018	NEW	$109,938
														Subtotal = $109,938

Grand Total All Awards = $440,556

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Investigating dopaminergic neuronal circuits mediating circadian entrainment to scheduled feeding

Award Number: SC3GM125570

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/13/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2023

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