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Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target

Award Number: SC3GM122629
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target - Project Summary Neglected and emerging tropical diseases caused by eukaryotic pathogens impact hundreds of millions of the world's population. These diseases are largely endemic to Asia, the Middle East, Africa, South and Central America, yet they pose a significant threat to global public health, including that of the United States. Hence, continued effort to control, eliminate, and provide safe and effective treatment options is crucial. In this SC3 project, our efforts will be devoted to the optimization, identification, and validation of new chemical entities as potential pre-clinical drug candidates for malaria, caused by Plasmodium falciparum, and Human African trypanosomiasis (HAT), caused by T. brucei gambiense/rhodesiense. We have identified a series of chemical entities that will serve as templates for further discovery and development. In this project, we will employ a combination of structure-, and natural products–based drug discovery approaches. In addition, we will structurally characterize the molecular interactions between the cysteine protease-drug target from T. brucei and its inhibitors. The successful execution of the aims and objectives for this project will add to the knowledge of structural chemotypes important for antitrypanosomal and antimalarial drug discovery, and it will add to the drug development pipeline for HAT and Leishmaniasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $4,693 )
2022	2020	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	4	10/17/2021	NON-COMPETING CONTINUATION	$41,213
2022	2020	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	001	4	10/29/2021	NON-COMPETING CONTINUATION	-$36,520
														Subtotal = $4,693

Issue Date FY: 2021 ( Subtotal = -$41,213 )
2021	2020	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	001	4	9/19/2021	NON-COMPETING CONTINUATION	-$41,213
2021	2020	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	4	6/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = -$41,213

Issue Date FY: 2020 ( Subtotal = $113,250 )
2020	2020	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	4	7/31/2020	NON-COMPETING CONTINUATION	$113,250
														Subtotal = $113,250

Issue Date FY: 2019 ( Subtotal = $113,250 )
2019	2019	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	3	8/22/2019	NON-COMPETING CONTINUATION	$113,250
														Subtotal = $113,250

Issue Date FY: 2018 ( Subtotal = $113,250 )
2018	2018	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	2	8/20/2018	NON-COMPETING CONTINUATION	$113,250
														Subtotal = $113,250

Issue Date FY: 2017 ( Subtotal = $113,250 )
2017	2017	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	1	9/15/2017	NEW	$113,250
														Subtotal = $113,250

Grand Total All Awards = $416,480

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Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target

Award Number: SC3GM122629

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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