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Effect of low-intensity versus moderate-intensity endurance exercise on physical functioning among breast cancer survivors: a randomized controlled trial

Award Number: SC3GM116684
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary As stated in the original scope of the project, improvements in early diagnosis and treatment for breast cancer in women have resulted in increased survivorship. An unintended consequence of increased survival, however, is that more women are living with the negative sequelae associated with cancer treatment, including decreased physical function. Exercise has been beneficial in arresting these sequelae, but adherence to exercise guidelines continues to be a challenge. As most breast cancer survivors are middle-aged and older, an alternative to standard exercise programming is to foster low intensity exercise program but there is little information about the potential benefits of low intensity programming. The overall purpose of this study is to assess the impact of a low intensity versus moderate intensity endurance exercise program on the physical function of breast cancer survivors. Our hypothesis is that participants in the low intensity exercise program will demonstrate similar physical functioning as participants in the moderate intensity exercise program. The Theory of Planned Behavior serves as the framework for the intervention. A convenience sample of 142 women, residents of Puerto Rico, age 50 or older, with a diagnosis of breast cancer (stage 0 thru III), who have received treatment for breast cancer (with or without adjuvant therapy) are randomly assigned to a low intensity or moderate intensity endurance intervention. Both interventions are home-based, have a duration of 6 months, with education and guidance provided at our facilities by physical therapists at each exercise session. An evaluator, blinded to group assignment, assesses participants at baseline and at the completion of the intervention. Primary outcome measures consist of physical functioning and health-related quality of life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$26,275 )
2022	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	4	7/29/2022	NON-COMPETING CONTINUATION	-$26,275
														Subtotal = -$26,275

Issue Date FY: 2021 ( Subtotal = -$9,388 )
2021	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	000	4	6/26/2021	SUPPLEMENT FOR EXPANSION	-$9,388
														Subtotal = -$9,388

Issue Date FY: 2019 ( Subtotal = $225,000 )
2019	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	4	4/26/2019	NON-COMPETING CONTINUATION	$112,500
2019	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Extramural Research Restoration Program: Hurricanes Harvey, Maria, and Irma – non-construction	001	4	4/29/2019	SUPPLEMENT FOR EXPANSION	$112,500
														Subtotal = $225,000

Issue Date FY: 2018 ( Subtotal = $112,500 )
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	3	2/21/2018	NON-COMPETING CONTINUATION	$101,250
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	3	5/11/2018	NON-COMPETING CONTINUATION	$11,250
														Subtotal = $112,500

Issue Date FY: 2017 ( Subtotal = $112,500 )
2017	2017	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	2	2/10/2017	NON-COMPETING CONTINUATION	$101,250
2017	2017	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	2	6/20/2017	NON-COMPETING CONTINUATION	$11,250
														Subtotal = $112,500

Issue Date FY: 2016 ( Subtotal = $112,500 )
2016	2016	UNIVERSITY OF PUERTO RICO - MEDICAL SCIENCE CAMPUS	POST OFFICE BOX 365067	SAN JUAN	PR			USA	Biomedical Research and Research Training	000	1	3/11/2016	NEW	$112,500
														Subtotal = $112,500

Grand Total All Awards = $526,837

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Effect of low-intensity versus moderate-intensity endurance exercise on physical functioning among breast cancer survivors: a randomized controlled trial

Award Number: SC3GM116684

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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