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Enhancement of Neuronal Plasticity and Axon Regeneration Capabilities of Pro-Neur

Award Number: SC3GM109785
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/09/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2019

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Enhancement of Neuronal Plasticity and Axon Regeneration Capabilities of Pro-Neur - DESCRIPTION (provided by applicant): Humans, as warm-blooded vertebrates, do not regenerate axons in their central nervous system (CNS) spontaneously. Conversely, cold-blooded vertebrates demonstrate remarkable abilities for nerve regeneration in their CNS. Studies of the molecular mechanisms of nerve regeneration have led to the discovery of several proteins that are induced during successful nerve regeneration. Analysis of the teleost fish optic nerve regeneration system led us to the identification of the RICH proteins. Several mutant versions of zebrafish RICH (zRICH) proteins have been generated and studied in our laboratory at the biochemical and cellular levels. This protein is a 2', 3'-cyclic nucleotide, 3'-phosphodiesterase that can bind to cellular membranes through a C-terminal membrane localization domain. Interestingly, our recent studies have shown that zRICH can bind to tubulin and enhance neuronal plasticity by promoting the formation of neurite branches. The central domain of the protein is sufficient for interaction with tubulin, but not for induction of neuritogenesis. One of the aims of this project is to learn additional details about the effects of zRICH in neuronal plasticity. Additional mutant versions of zRICH will be studied with our PC12 differentiation model, to learn whether the membrane localization domain or the acidic N-terminal domain play roles in neuritogenesis. A second aim is to explore the possibility of synergism of zRICH with other neuronal plasticity enhancing proteins such as GAP43 and CAP23. A third goal is exploring whether the plasticity enhancing effects can be applied to neural stem cells. The studies are relevant to public health by providing a better understanding of the process of nerve regeneration, and novel tools for the treatment of human diseases caused by damage to nerve fibers in the CNS, for example spinal cord injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$106 )
2021	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	4	7/30/2021	NON-COMPETING CONTINUATION	$488
2021	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	001	4	8/3/2021	NON-COMPETING CONTINUATION	-$594
														Subtotal = -$106

Issue Date FY: 2019 ( Subtotal = -$488 )
2019	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	4	9/5/2019	NON-COMPETING CONTINUATION	-$488
														Subtotal = -$488

Issue Date FY: 2017 ( Subtotal = $103,500 )
2017	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	001	4	6/20/2017	NON-COMPETING CONTINUATION	$10,350
2017	2017	TEXAS A & M UNIVERSITY KINGSVILLE	700 UNIVERSITY BLVD	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	4	4/25/2017	NON-COMPETING CONTINUATION	$93,150
														Subtotal = $103,500

Issue Date FY: 2016 ( Subtotal = $103,500 )
2016	2016	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	3	5/18/2016	NON-COMPETING CONTINUATION	$103,500
														Subtotal = $103,500

Issue Date FY: 2015 ( Subtotal = $103,500 )
2015	2015	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	2	4/21/2015	NON-COMPETING CONTINUATION	$103,500
														Subtotal = $103,500

Issue Date FY: 2014 ( Subtotal = $103,500 )
2014	2014	TEXAS A & M UNIVERSITY	STATION 1	KINGSVILLE	TX	78363	KLEBERG	USA	Biomedical Research and Research Training	000	1	6/3/2014	NEW	$103,500
														Subtotal = $103,500

Grand Total All Awards = $413,406

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Enhancement of Neuronal Plasticity and Axon Regeneration Capabilities of Pro-Neur

Award Number: SC3GM109785

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/09/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2019

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