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Regulation of Sperm Cell Differentiation in C. elegans

Award Number: SC3GM087212
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2009
PERIOD OF PERFORMANCE END DATE: 05/31/2022

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Regulation of Sperm Cell Differentiation in C. elegans - DESCRIPTION (provided by applicant): Major cellular events are typically regulated through the interaction of promoting and inhibiting factors, but an understanding of all the antagonistic factors and their interactions is generally incomplete for most cellular events. This proposal focuses on the antagonistic regulation of spermatid activation C. elegans. Also called spermiogenesis, this wholesale cellular reorganization involves regulated vesicle exocytosis, pseudopod formation, and the induction of motility, transforming spherical spermatids into amoeboid spermatozoa. Spermiogenesis occurs when spermatids encounter an activation signal that is transduced into the cell via a signaling complex of five gene products. Spermiogenesis is inhibited directly by the protein SPE-6, while another set of proteins contribute to the formation of a specialized organelle that also inhibits spermiogenesis: the Fibrous Body-Membranous Organelle (FB-MO). With both promoting and inhibiting factors, spermiogenesis in C. elegans is an ideal model system for investigation of antagonistic regulation. Further, preliminary data show that activation and inhibition converge on the SPE-6 protein. While five of the gene products involved in the regulation of sperm activation have been identified, a collection of mutations defining additional regulatory genes remains to be investigated, so knowledge of the antagonistic regulation of spermiogenesis is incomplete. Thus, there is an important need to uncover more of the regulatory proteins and to investigate their interactions. The long-term goal of the research is to gain a more comprehensive understanding of the antagonistic regulation of sperm activation in C. elegans. The central hypothesis of the research is that the signal promoting spermiogenesis is transduced into the cell where it relieves inhibition by down-regulating SPE-6 and by altering FB-MO function. The rationale for the proposed research is that it will enable identification of more of the proteins involved in spermiogenesis regulation, and it will contribute to knowledge of the function, localization, and interactions of these proteins. The expected outcomes of the proposed research are that 3 to 5 new spermiogenesis regulation genes will be identified and their functional roles will be established. Further, the role of SPE-6 protein as the intersection between signaling and inhibition will be determined. These results are expected to have a positive impact, because they will provide a more comprehensive understanding of the antagonistic regulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$41 )
2023	2019	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	8	11/5/2022	NON-COMPETING CONTINUATION	-$41
														Subtotal = -$41

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	8	5/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $108,750 )
2019	2019	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	8	6/5/2019	NON-COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2018 ( Subtotal = $108,750 )
2018	2018	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	7/5/2018	NON-COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2017 ( Subtotal = $108,750 )
2017	2017	CAL POLY POMONA FOUNDATION INC	3801 W TEMPLE AVE	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	6	5/26/2017	NON-COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2016 ( Subtotal = $108,750 )
2016	2016	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	5	3/31/2016	COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2012 ( Subtotal = $105,435 )
2012	2012	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	5/21/2012	NON-COMPETING CONTINUATION	$105,435
														Subtotal = $105,435

Issue Date FY: 2011 ( Subtotal = $105,435 )
2011	2011	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	5/23/2011	NON-COMPETING CONTINUATION	$105,435
														Subtotal = $105,435

Issue Date FY: 2010 ( Subtotal = $237,102 )
2010	2010	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	001	2	5/12/2010	NON-COMPETING CONTINUATION	$106,500
2010	2010	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	000	1	2/26/2010	SUPPLEMENT FOR EXPANSION	$130,602
														Subtotal = $237,102

Issue Date FY: 2009 ( Subtotal = $106,500 )
2009	2009	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	4/9/2009	NEW	$106,500
2009	2009	CAL POLY POMONA FOUNDATION, INC	3801 WEST TEMPLE AVE, BLDG 55	POMONA	CA	91768	LOS ANGELES	USA	Biomedical Research and Research Training	001	1	4/17/2009	NEW	$0
														Subtotal = $106,500

Grand Total All Awards = $989,431

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Regulation of Sperm Cell Differentiation in C. elegans

Award Number: SC3GM087212

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2009

PERIOD OF PERFORMANCE END DATE: 05/31/2022

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