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IDENTIFICATION AND MOLECULAR BASIS FOR EFFICIENT ANTIFREEZE PROTEIN ENHANCERS

Award Number: SC3GM086249
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2009
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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IDENTIFICATION AND MOLECULAR BASIS FOR EFFICIENT ANTIFREEZE PROTEIN ENHANCERS - Abstract/Summary Antifreeze proteins (AFPs) are natural antifreeze molecules that have been found in many organisms including fish, insects, plants, bacteria, and fungi. AFPs exhibit great structural diversity, while they are all characterized by their unique ability to depress the freezing point of water without affecting the melting point apparently. The resulting difference between the melting point and the freezing point, referred to as thermal hysteresis (TH), is generally used as a measure of the antifreeze activities of AFPs. AFPs and co-solutes in body-fluids of cold-adapted organisms are responsible for survival in cold environments. Certain small molecule and protein co-solutes can further enhance the antifreeze activity of AFPs, referred to as enhancers, by binding to AFP through ionic interactions, hydrogen bonding, and/or hydrophobic interactions. AFP-based antifreeze systems (AFP plus enhancer) are much more effective and their uses are more environmentally friendly in comparison to conventional antifreezes, making them intriguing alternatives to conventional antifreezes in particular in biomedical fields. The proposed research will investigate the little known AFP- protein systems through determining the cryoprotective effect of an AFP on other proteins as well as the effect of these proteins on the antifreeze activity of the AFP using combined biochemical and biophysical methods. The information on such interplay in the AFP-protein systems would not only further our understanding of biological antifreeze system in cold-adapted organisms, but also lead to the development of effective protective systems for long-term preservation of important biologics in biomedical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $109,500 )
2023	2023	CAL STATE LA UNIVERSITY AUXILIARY SERVICES INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	15	8/10/2023	NON-COMPETING CONTINUATION	$109,500
														Subtotal = $109,500

Issue Date FY: 2022 ( Subtotal = $109,500 )
2022	2022	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	14	8/16/2022	NON-COMPETING CONTINUATION	$109,500
														Subtotal = $109,500

Issue Date FY: 2021 ( Subtotal = $109,500 )
2021	2021	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	002	13	8/10/2021	NON-COMPETING CONTINUATION	$109,500
2021	2020	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	12	6/7/2021	COMPETING CONTINUATION	$47,077
2021	2019	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	11	6/7/2021	NON-COMPETING CONTINUATION	-$47,077
														Subtotal = $109,500

Issue Date FY: 2020 ( Subtotal = $109,500 )
2020	2020	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	12	9/23/2020	COMPETING CONTINUATION	$109,500
2020	2019	CAL STATE L.A. UNIVERSITY AUXILIARY SERVICES, INC.	5151 STATE UNIVERSITY DR GE 314	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	11	9/22/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $109,500

Issue Date FY: 2019 ( Subtotal = $109,500 )
2019	2019	CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	11	5/2/2019	NON-COMPETING CONTINUATION	$109,500
														Subtotal = $109,500

Issue Date FY: 2018 ( Subtotal = $109,500 )
2018	2018	CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	10	5/14/2018	NON-COMPETING CONTINUATION	$109,500
														Subtotal = $109,500

Issue Date FY: 2017 ( Subtotal = $109,500 )
2017	2017	CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	002	9	5/30/2017	NON-COMPETING CONTINUATION	$109,500
2017	2016	CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	8	11/29/2016	COMPETING CONTINUATION	$29,412
2017	2015	CALIFORNIA STATE UNIVERSITY AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DR	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	11/29/2016	NON-COMPETING CONTINUATION	-$29,412
														Subtotal = $109,500

Issue Date FY: 2016 ( Subtotal = $109,500 )
2016	2016	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	8	4/14/2016	COMPETING CONTINUATION	$109,500
2016	2015	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	4/8/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $109,500

Issue Date FY: 2015 ( Subtotal = $108,750 )
2015	2015	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	3/10/2015	NON-COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2014 ( Subtotal = $108,750 )
2014	2014	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	6	3/17/2014	NON-COMPETING CONTINUATION	$108,750
														Subtotal = $108,750

Issue Date FY: 2013 ( Subtotal = $104,944 )
2013	2013	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	5	5/31/2013	NON-COMPETING CONTINUATION	$7,069
2013	2013	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	5	2/22/2013	NON-COMPETING CONTINUATION	$97,875
														Subtotal = $104,944

Issue Date FY: 2012 ( Subtotal = $108,750 )
2012	2012	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	4	3/23/2012	COMPETING CONTINUATION	$108,750
2012	2011	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	3/23/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $108,750

Issue Date FY: 2011 ( Subtotal = $107,291 )
2011	2011	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	1/31/2011	NON-COMPETING CONTINUATION	$97,538
2011	2011	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	6/8/2011	NON-COMPETING CONTINUATION	$9,753
														Subtotal = $107,291

Issue Date FY: 2010 ( Subtotal = $108,375 )
2010	2010	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	1/19/2010	NON-COMPETING CONTINUATION	$108,375
														Subtotal = $108,375

Issue Date FY: 2009 ( Subtotal = $214,048 )
2009	2009	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	12/12/2008	NEW	$108,375
2009	2009	CAL ST LA UNIV AUXILIARY SERVICES, INC	5151 STATE UNIVERSITY DRIVE	LOS ANGELES	CA	90032	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	001	1	9/22/2009	SUPPLEMENT FOR EXPANSION	$105,673
														Subtotal = $214,048

Grand Total All Awards = $1,736,908

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IDENTIFICATION AND MOLECULAR BASIS FOR EFFICIENT ANTIFREEZE PROTEIN ENHANCERS

Award Number: SC3GM086249

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2009

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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