Tuesday, November 4, 2025 11/4/2025

Discovery of Novel Antibiotic Natural Products from Marine-Derived Fungi

Award Number: SC2GM144172
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/25/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Discovery of Novel Antibiotic Natural Products from Marine-Derived Fungi - Project Summary/Abstract A major challenge facing the future of human health is the rise of antibiotic-resistant pathogenic bacteria. In 2017 the World Health Organization (WHO) published a list of twelve pathogens that will pose the greatest threat to human health due to resistance to frontline treatments. The overall goal of this project will be to identify novel fungal natural products that exhibit antibiotic activity towards the WHO pathogens. Natural products are secondary metabolites produced by living organisms. These small molecule chemical entities have played an important role in traditional medicine for thousands of years and are an essential part of the current therapeutic arsenal for modern medicine. This project will achieve the overall goal through two areas of research. The first area involves the development of a rapid dereplication method that reduces redundant fungal strains in culture libraries to streamline biological screening. The second involves the identification of antibiotic drug-leads with novel chemical scaffolds or that function through a unique antivirulence mechanism of action against the WHO pathogens. Once completed, these two areas of research will be bridged to develop a fungal metabolite drug discovery platform that will be used to promote future lines of biomedical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$42,788 )
2025	2024	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	9/18/2025	NON-COMPETING CONTINUATION	-$42,788
														Subtotal = -$42,788

Issue Date FY: 2024 ( Subtotal = $147,000 )
2024	2024	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	4/22/2024	NON-COMPETING CONTINUATION	$132,300
2024	2024	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	6/18/2024	NON-COMPETING CONTINUATION	$14,700
														Subtotal = $147,000

Issue Date FY: 2023 ( Subtotal = $147,000 )
2023	2023	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	4/4/2023	NON-COMPETING CONTINUATION	$147,000
														Subtotal = $147,000

Issue Date FY: 2022 ( Subtotal = $147,000 )
2022	2022	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	5/25/2022	NEW	$147,000
														Subtotal = $147,000

Grand Total All Awards = $398,212

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Discovery of Novel Antibiotic Natural Products from Marine-Derived Fungi

Award Number: SC2GM144172

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/25/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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