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DNA methylation biomarkers and ancestry in breast cancer in Hispanic women

Award Number: SC2GM130476
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2022

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DNA methylation biomarkers and ancestry in breast cancer in Hispanic women - ABSTRACT Hispanic women have a lower incidence of breast cancer than non-Hispanic white and African American women; however, they are more likely to die from the disease. They are diagnosed at younger ages and have higher rates of high grade and estrogen receptor-negative tumors, which all lead to poorer prognosis. The extent to which genetic and environmental factors play a role in these disparities has not been fully elucidated. The main goal of this proposal is to identify DNA methylation marks in Hispanic women that are associated with breast cancer taking into consideration the racial subgroups of the Hispanic popula- tion. This study will address the following specific aims: 1) determine the association between DNA methylation biomarkers and breast cancer prognostic markers in high-risk Hispanic women, and 2) identi- fy DNA methylation biomarkers of breast cancer in Hispanic women considering ancestry. It will also use ances- try informative markers (AIMs) already identified in the literature to characterize the differential contri- bution of racial backgrounds to DNA methylation biomarkers in this disease. The project will address whether DNA methylation panels (epitypes) used in the classification of breast cancer tumors which have prognostic and treatment potential, can be used in a racially and ethnically diverse cohort of high-risk women. The first aim will focus on whether known current epitypes can identify samples at higher risk of mortality and whether clustering is modified by genetic ancestry. The second aim's goal is to identify breast tumor DNA methylation marks specific to Hispanic women. Both analysis will be carried in breast cancer cases from the New York site of the Breast Cancer Family Registry (BCFR). Using the BCFR is ideal because it has already collected biospecimens and detailed epidemiological data This study will be the first focusing on DNA methylation biomarkers in a population of Hispanic breast cancer cases. The inclusion of ancestry informative markers to determine the admixture substructure of the study population in association with DNA methylation is also novel. This research is expected to aid in the identification of individuals with higher risk of mortality, and ultimately lead to targeted treatments to reduce breast cancer mortality in this population. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	524 W 59TH ST	NEW YORK	NY	10019	NEW YORK	USA	Biomedical Research and Research Training	000	3	7/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $120,865 )
2020	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	524 W 59TH ST	NEW YORK	NY	10019	NEW YORK	USA	Biomedical Research and Research Training	000	3	8/24/2020	NON-COMPETING CONTINUATION	$120,865
														Subtotal = $120,865

Issue Date FY: 2019 ( Subtotal = $120,865 )
2019	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	524 W 59TH ST	NEW YORK	NY	10019	NEW YORK	USA	Biomedical Research and Research Training	000	2	9/10/2019	NON-COMPETING CONTINUATION	$120,865
														Subtotal = $120,865

Issue Date FY: 2018 ( Subtotal = $120,865 )
2018	2018	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	524 W 59TH ST	NEW YORK	NY	10019	NEW YORK	USA	Biomedical Research and Research Training	000	1	9/12/2018	NEW	$120,865
														Subtotal = $120,865

Grand Total All Awards = $362,595

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DNA methylation biomarkers and ancestry in breast cancer in Hispanic women

Award Number: SC2GM130476

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2022

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