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High precision pharmacokinetic measurements in brain using a novel aptamer-based biosensor

Award Number: SC2GM127268
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/22/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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High precision pharmacokinetic measurements in brain using a novel aptamer-based biosensor - Project Summary/Abstract Abstract: High precision pharmacokinetic measurements in brain using a novel aptamer-based biosensor DESCRIPTION The addiction potential of a drug is related to the rate at which it interacts with the brain. Drug abuse is particularly problematic for prescribed therapeutic drugs as they are a major contributor to the current addiction epidemic. In order to increase drug efficacy and mitigate toxicity, it is crucial to monitor drug pharmacokinetics. Traditional methods for monitoring drug pharmacokinetics require the removal of samples from the brain by microdialysis for later analysis in the laboratory, rendering them slow and cumbersome and greatly limiting their temporal resolution. In contrast, the development of a novel electrochemical aptamer-based (E-AB) biosensor by the mentor's group has opened the door for the continuous, ultra-high-resolution monitoring of drugs in living subjects. For example, the PI has already used this technology to measure multiple drug targets, demonstrating accurate, high-precision (seconds-resolved) pharmacokinetic tracking of these compounds over multiple hours in a live animal model. To expand this promising platform for understanding drug metabolism, the PI will apply it to characterizing the pharmacokinetics of compounds that cross the blood-brain barrier (BBB). These will include the prescription opioid oxycodone and the addictive illicit drug cocaine. Here, the PI intends to implement E-AB sensors to measure the real-time pharmacokinetics these compounds in brain, thus not only improving our understanding of the time course of drugs crossing the BBB, but to also demonstrate the functionality of this potentially revolutionary new pharmacokinetic tool. To that end, the PI proposes the following specific aims: 1) Expansion of high precision in vitro use of E-AB sensors to novel drug targets; 2) Expansion of E-AB sensors to measurements in the brain. Successful completion of these aims will not only establish this novel technology and methodology in the PI's laboratory, but will also further develop the technology to measure new, clinically-relevant compounds in a new and important location. Additionally, this work will help develop the PI as an independent research investigator to seek non-SCORE support in the future to expand his research program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$23,026 )
2025	2021	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	7/18/2025	NON-COMPETING CONTINUATION	-$23,026
														Subtotal = -$23,026

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	CALIFORNIA STATE UNIVERSITY, DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	7/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	6/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $142,300 )
2021	2021	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	5/20/2021	NON-COMPETING CONTINUATION	$142,300
														Subtotal = $142,300

Issue Date FY: 2020 ( Subtotal = $142,300 )
2020	2020	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	001	2	5/29/2020	NON-COMPETING CONTINUATION	$142,300
2020	2019	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	5/28/2020	NEW	$0
														Subtotal = $142,300

Issue Date FY: 2019 ( Subtotal = $137,600 )
2019	2019	CALIFORNIA STATE UNIVERSITY DOMINGUEZ HILLS FOUNDATION	1000 E VICTORIA ST	CARSON	CA	90747	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	8/22/2019	NEW	$137,600
														Subtotal = $137,600

Grand Total All Awards = $399,174

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High precision pharmacokinetic measurements in brain using a novel aptamer-based biosensor

Award Number: SC2GM127268

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/22/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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