Friday, July 4, 2025 7/4/2025

Elucidating the role of MeCP2 in the pathophysiology of obesity

Award Number: SC1GM144190
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2026

Group Awards By:

View Award Description

Elucidating the role of MeCP2 in the pathophysiology of obesity - Project summary Obesity is a severely debilitating disease state that afflicts 650 million people worldwide. The increased prevalence of obesity is associated with a number of other diseases such as diabetes, cardiovascular disease, and hypertension. Given its implications for health care, it is now considered a global epidemic by the World Health Organization. These alarming statistics call for a need to understand neurobiological mechanisms that underlie the development of obesity. The goal of the current proposal is to understand the role that methyl- CpG-binding protein 2 (MeCP2) plays in the etiology of obesity. Recent studies implicate a role of this neuroepigenetic regulator in precipitating obesity in mouse models and in children diagnosed with Prader-Willi Syndrome, a neurodevelopmental disorder characterized by hyperphagia and marked obesity. The current proposal will utilize transgenic mouse models in which Mecp2 is knocked out in order to understand the neurobiological consequences of Cre-lox mediated knock out of this epigenetic factor in hypothalamic pro- opiomelanocortin (POMC) neurons. Another goal of this proposal is to understand how POMC-specific knockout of Mecp2 can alter behavioral responses to food. The data from this proposal will elucidate the role that MeCP2 plays on the development of obesity and may ultimately lead to therapeutic strategies with which to combat the obesity epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $295,450 )
2024	2024	TEXAS WOMANS UNIVERSITY	304 ADMINISTRATION DRIVE	DENTON	TX	76204	DENTON	USA	Biomedical Research and Research Training	000	3	5/31/2024	NON-COMPETING CONTINUATION	$295,450
														Subtotal = $295,450

Issue Date FY: 2023 ( Subtotal = $295,450 )
2023	2023	TEXAS WOMAN'S UNIVERSITY	304 ADMINISTRATION DR	DENTON	TX	76204	DENTON	USA	Biomedical Research and Research Training	000	2	5/26/2023	NON-COMPETING CONTINUATION	$295,450
														Subtotal = $295,450

Issue Date FY: 2022 ( Subtotal = $295,450 )
2022	2022	TEXAS WOMAN'S UNIVERSITY	304 ADMINISTRATION DR	DENTON	TX	76204	DENTON	USA	Biomedical Research and Research Training	000	1	7/8/2022	NEW	$295,450
														Subtotal = $295,450

Grand Total All Awards = $886,350

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Elucidating the role of MeCP2 in the pathophysiology of obesity

Award Number: SC1GM144190

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer