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Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents

Award Number: SC1GM140990
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/09/2021
PERIOD OF PERFORMANCE END DATE: 04/29/2024

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Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents - Project Summary Pathogenic protozoans cause several neglected, persistent, and emerging tropical diseases. These diseases impact hundreds of millions of people worldwide, and they pose significant threat to global public health, including that of the United States. The key problems of tropical diseases are limited access to effective drugs, inadequate diagnostic tools, and development of drug resistance to existing drugs by the etiological agents. Hence, continued effort to control, eliminate, and provide safe and effective treatment options is crucial. In this SC1 project, our efforts will be devoted to investigating new chemical entities that can serve as drug leads for human African trypanosomiasis (HAT) and Chagas disease. The main objective is to investigate chemical entities that can suppress the development of drug resistance by protozoan parasites to clinically used nitroaromatic drugs. We envision that the studies outlined in this project will propel preclinical studies of new generation antitrypanosomal agents that possess multiple mechanisms of action. In addition, we expect that successful implementation of the aims and objectives of this project will produce innovative and fundamental knowledge on antitrypanosomal agents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$474,153 )
2024	2023	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	002	3	9/19/2024	NON-COMPETING CONTINUATION	-$373,002
2024	2023	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	3	7/12/2024	NON-COMPETING CONTINUATION	$0
2024	2022	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	001	2	9/19/2024	NON-COMPETING CONTINUATION	-$101,151
														Subtotal = -$474,153

Issue Date FY: 2023 ( Subtotal = $373,002 )
2023	2023	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	3	6/20/2023	NON-COMPETING CONTINUATION	$373,002
														Subtotal = $373,002

Issue Date FY: 2022 ( Subtotal = $362,952 )
2022	2022	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	2	6/29/2022	NON-COMPETING CONTINUATION	$362,952
														Subtotal = $362,952

Issue Date FY: 2021 ( Subtotal = $357,520 )
2021	2021	JACKSON STATE UNIVERSITY	1400 J R LYNCH ST STE 206	JACKSON	MS	39217	HINDS	USA	Biomedical Research and Research Training	000	1	7/6/2021	NEW	$357,520
														Subtotal = $357,520

Grand Total All Awards = $619,321

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Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents

Award Number: SC1GM140990

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/09/2021

PERIOD OF PERFORMANCE END DATE: 04/29/2024

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