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Retraction or reshaping: dissecting the role of mitochondrial ROS in synaptic plasticity

Award Number: SC1GM136609
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Retraction or reshaping: dissecting the role of mitochondrial ROS in synaptic plasticity - PROJECT SUMMARY Neuronal function requires the reshaping and rewiring of neural connections through a fundamental process named synaptic plasticity. It is well known that the strength of neurotransmission is regulated by feedback signaling between the pre- and postsynaptic neuron, which leads to short- and/or long-term structural adaptations. However, little is known about how this regulation occurs. The current objective is to elucidate this missing mechanistic link by exploring emerging signaling roles of mitochondria, which are organelles that sustain the local energy demand of synaptic function and plasticity. Based on the rationale that neuronal activity sets the pace of aerobic energy conversion and of emission of chemically reactive oxygen species (ROS) from mitochondria, we hypothesize that controlled and localized mitochondrial emission of ROS regulates synaptic function and plasticity. Our preliminary data show that emission of mitochondrial ROS can be elicited specifically in presynaptic terminals in vivo. We will pioneer in the use of optogenetics for synchronized induction and measurement of ROS emission during synaptic function. Functional ROS signaling targets will be explored using super resolution fluorescence microscopy and mass spectrometry. Importantly, our collaborators and we established a method to elicit and study synaptic plasticity within just a few hours using optogenetics in vivo. Our results will impact therapies aimed improving neuronal communication in age-related neurodegeneration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $359,752 )
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	ONE BERNARD BARUCH WAY BOX J-1010	NEW YORK	NY	10010	NEW YORK	USA	Biomedical Research and Research Training	000	4	5/11/2023	NON-COMPETING CONTINUATION	$359,752
														Subtotal = $359,752

Issue Date FY: 2022 ( Subtotal = $356,593 )
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	ONE BERNARD BARUCH WAY BOX J-1010	NEW YORK	NY	10010	NEW YORK	USA	Biomedical Research and Research Training	000	3	5/17/2022	NON-COMPETING CONTINUATION	$356,593
														Subtotal = $356,593

Issue Date FY: 2021 ( Subtotal = $353,626 )
2021	2021	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	ONE BERNARD BARUCH WAY BOX J-1010	NEW YORK	NY	10010	NEW YORK	USA	Biomedical Research and Research Training	000	2	5/20/2021	NON-COMPETING CONTINUATION	$353,626
														Subtotal = $353,626

Issue Date FY: 2020 ( Subtotal = $350,676 )
2020	2020	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	ONE BERNARD BARUCH WAY BOX J-1010	NEW YORK	NY	10010	NEW YORK	USA	Biomedical Research and Research Training	000	1	8/5/2020	NEW	$350,676
														Subtotal = $350,676

Grand Total All Awards = $1,420,647

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Retraction or reshaping: dissecting the role of mitochondrial ROS in synaptic plasticity

Award Number: SC1GM136609

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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