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Bioactive cellulose-nanodiamond (CeND) scaffolds for applications in craniofacial bone tissue regeneration

Award Number: SC1GM127220
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The long-term goal of this research is to develop a semi-rigid bioactive scaffold based on cellulose- nanodiamond (CeND) porous fibers for craniofacial bone tissue regeneration. The bioactive scaffolds will be prepared in the form of fibers using the electrospining technique. The CeND are modified with growth and adhesion factors aiming to improve the rate of bone tissue regeneration. We will achieve the overall goal of this research by pursuing three main specific aims: 1) To formulate bioactive CeND solutions to generate porous scaffolds; 2) To evaluate the biocompatibility of the bioactive CeND scaffolds in vitro using a bioreactor to generate 3D tissue models; 3) To determine the osteoinductive capacity of bioactive CeND scaffolds in cranial defects in rats. We hypothesize that by incorporating osteoinductive growth factors (i.e. BMP-2) along with adhesion factors (i.e. KSRS and RGD peptides) in CeND-fibered scaffolds, we will be able to enhance the deposition rate of newly formed mineralized tissue along the scaffold. Once the bioactive scaffolds are fabricated we will physically, mechanically and biologically characterize the fibers with and without the growth and adhesion factors. The biological characterization will be performed in-vitro utilizing human mesenchymal stem cells (MSCs). Specifically, we will use inmmunohistochemical techniques to determine the ability of the cells to growth, mature, adhere and differentiate when in contact with the bioactive flexible scaffolds. The in- vitro experiments will be performed in Slow-Turning Lateral Vessel (STLV) bioreactor in order to generate 3D tissue models over the scaffolds. We expect that this in-vitro technique will allow us to better predict the performance of the scaffolds in-vivo. We will be able to answer fundamental questions regarding cell-surface interactions with the goal of proposing a flexible bioactive scaffold with enhanced biomimetic properties. This work will shed light on the use of semi-rigid scaffolds for craniofacial bone tissue regeneration and repair that is of utmost importance to tackle medical conditions such as the cleft palate and other craniomaxillofacial conditions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $372,500 )
2022	2022	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	4	8/25/2022	NON-COMPETING CONTINUATION	$372,500
2022	2022	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	001	4	9/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $372,500

Issue Date FY: 2021 ( Subtotal = $372,500 )
2021	2021	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	3	8/10/2021	NON-COMPETING CONTINUATION	$372,500
														Subtotal = $372,500

Issue Date FY: 2020 ( Subtotal = $300,965 )
2020	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	001	2	8/17/2020	NON-COMPETING CONTINUATION	$300,965
2020	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	1	4/17/2020	NEW	$0
														Subtotal = $300,965

Issue Date FY: 2019 ( Subtotal = $305,664 )
2019	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Biomedical Research and Research Training	000	1	8/23/2019	NEW	$305,664
														Subtotal = $305,664

Grand Total All Awards = $1,351,629

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Bioactive cellulose-nanodiamond (CeND) scaffolds for applications in craniofacial bone tissue regeneration

Award Number: SC1GM127220

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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