Thursday, November 21, 2024 11/21/2024

In Vivo Neuroprotective Properties and Action Mechanism(s) of Plant-produced Asialo-erythropoietin

Award Number: SC1GM111178
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract There is an acute need to develop neuroprotective drugs to prevent or/and protect neuronal cell damage and death caused by ischemia/reperfusion, hypoxia or cytotoxic agents in the brain. Plant- based expression system can be used to produce asialo-rhuEPO, a non-hematopoietic recombinant human EPO derivative lacking sialic acid, which could be used as a neuroprotective agent for preventing and protecting brain damage from ischemia/reperfusion injury. In our previous studies, we found that plant-produced asialo-rhuEPO (asialo-rhuEPOP) is non-erythropoietic and displays excellent neuroprotective effects in a young mouse model of middle cerebral artery occlusion (MCAO) I/R injury. Our previous studies have set the stage for the current proposed research activities. In this SC1 renewal application, we propose to extend asialo-rhuEPOP-mediated neuroprotection studies to aged mice, evaluate long-term neurological outcomes in both young and aged mice, and further understand its neuroprotective mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $370,000 )
2024	2024	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	8	4/30/2024	NON-COMPETING CONTINUATION	$370,000
														Subtotal = $370,000

Issue Date FY: 2023 ( Subtotal = $370,000 )
2023	2023	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	002	7	5/1/2023	NON-COMPETING CONTINUATION	$370,000
2023	2021	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	001	5	2/28/2023	COMPETING CONTINUATION	$15,429
2023	2020	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	4	2/28/2023	NON-COMPETING CONTINUATION	-$15,429
														Subtotal = $370,000

Issue Date FY: 2022 ( Subtotal = $370,000 )
2022	2022	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	6	5/2/2022	NON-COMPETING CONTINUATION	$370,000
														Subtotal = $370,000

Issue Date FY: 2021 ( Subtotal = $370,000 )
2021	2021	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	001	5	5/19/2021	COMPETING CONTINUATION	$370,000
2021	2020	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	4	5/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $370,000

Issue Date FY: 2020 ( Subtotal = $360,000 )
2020	2020	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	001	4	3/17/2020	NON-COMPETING CONTINUATION	$36,000
2020	2020	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	4	1/1/2020	NON-COMPETING CONTINUATION	$324,000
														Subtotal = $360,000

Issue Date FY: 2019 ( Subtotal = $360,000 )
2019	2019	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	3	12/28/2018	NON-COMPETING CONTINUATION	$360,000
														Subtotal = $360,000

Issue Date FY: 2018 ( Subtotal = $360,000 )
2018	2018	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	001	2	5/11/2018	NON-COMPETING CONTINUATION	$36,000
2018	2018	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	2	12/15/2017	NON-COMPETING CONTINUATION	$324,000
														Subtotal = $360,000

Issue Date FY: 2017 ( Subtotal = $360,000 )
2017	2017	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Biomedical Research and Research Training	000	1	12/27/2016	NEW	$360,000
														Subtotal = $360,000

Grand Total All Awards = $2,920,000

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In Vivo Neuroprotective Properties and Action Mechanism(s) of Plant-produced Asialo-erythropoietin

Award Number: SC1GM111178

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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