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Expansion of the Metabolic Profiling Core: The Sciex 7500+ LC/MS-MS System

Award Number: S10OD040226
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Expansion of the Metabolic Profiling Core: The Sciex 7500+ LC/MS-MS System - This SIG Grant details the critical need for a Sciex 7500+ QTrap liquid chromatography (LC)-tandem mass spectrometry (MS/MS) system to expand the capability of the Metabolic Profiling Core at the University of Louisville. The Core is the only core facility on campus to support the specialized, targeted lipidomic profiling needs of the fast-growing User base, which includes twenty-four investigators across eight NIH-funded centers and four universities in the fields of immunology, cardiovascular health, cancer, hepatic and metabolic disease, environmental toxicology, exercise science, and oral health. The justification for a new LC-MS/MS system is clear: 1) The growing volume, complexity, and sensitivity needs of our user base exceed the capabilities offered by our aging instrumentation. The current instrument now over a decade old suffers from limited sensitivity and insufficient dynamic range to meet current research demands, but most critically, it requires significant and frequent downtime due to instability and need for repair. 2) The limited available time limits the Core’s ability to develop new integrated lipidomic approaches, a unique feature of the Core, to meet the needs of investigators for their competitive grant applications and cutting-edge research projects. 3) No systems from other vendors have the combination of sensitivity, detection limit, scan speed, polarity switching, and dynamic range required for the detection and quantification of low-abundance analytes that the Sciex 7500+ provides. The Users’ more than $21 million (majorly NIH-funded) portfolios of grants have benefited from the Core’s existing Sciex 5500 system. As Sciex 5500 has entered end-of-sale stage and nearing end-of-service stage, the Sciex 7500+ is now the best option to expand the Core’s capability and capacity with the established high level analyses standard. The requested instrument will be housed in an existing core with a combined two-plus decades of experience with Sciex instrumentation. The existing Core leadership, space, ongoing financial support, and technical expertise guarantees effective use and maintenance of the requested instrument from day-one of its installations. The requested instrument will not only effectively expand the most needed capacity to meet the demand of the existing targeted lipidomic analyses; but also allow the Core to develop and provide new methodologies to quantify lipid classes currently not offered on campus for the Core’s User base. The over-arching theme among the Major Users are the continued need for precise, sensitive determination of changes lipid and lipid mediator abundance in complex biological samples. Over the next several years, procurement of this Sciex 7500+ system will allow the Metabolic Profiling Core to scale to meet the ever-growing investigators’ demand in NIH-funded cross-functional biomedical research projects and continue advancing scientific inquiry into the determinants of health and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $640,019 )
2026	2026	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Research Infrastructure Programs	000	1	6/19/2026	NEW	$640,019
														Subtotal = $640,019

Grand Total All Awards = $640,019

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Expansion of the Metabolic Profiling Core: The Sciex 7500+ LC/MS-MS System

Award Number: S10OD040226

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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